Purpose: The association between serum uric acid (SUA) and pulse wave velocity (PWV), has been extensively evaluated but with some discrepancies in results. A further limitation refers to the fact that only few data were analyzed taking into account the possible effects of gender. The purpose of this study was to estimate the association between SUA and arterial stiffness in general population and hypertensive patients, as a whole population and as divided by gender, by pooling results from existing studies.Materials and methods: Carotid-femoral and brachial-ankle PWV (cf- and ba-PWV) have been analyzed separately and subgroup analyses by gender are reported. Among 692 potentially relevant works, 24 articles were analyzed. Results: Seven studies referred to cf-PWV in the general population with an overall positive association at adjusted analysis for both males and females (beta regression coefficient (ß): 0.07; 95%CI: 0.03; 0.11 and ß: 0.06; 95%CI: 0.03; 0.09, respectively). Twelve studies referred to ba-PWV in the general population with the finding of a positive association at adjusted analysis for females (ß: 0.04; 95% confidence interval (CI): 0.01;0.07), but not for males (ß: 0.13; 95%CI: -0.09; 0.34). In hypertensive patients only four studies evaluated cf-PWV and one ba-PWV with only one study (with cf-PWV) finding positive association. Conclusion: The association between SUA and cf-PWV resulted significant in general population in both males and females while it was only significant for female regarding ba-PWV. Furthermore, the few available studies found no significant relationship between SUA and both cf- and ba-PWV in hypertensive subjects.
Purpose: The association between serum uric acid (SUA) and pulse wave velocity (PWV), has been extensively evaluated but with some discrepancies in results. A further limitation refers to the fact that only few data were analyzed taking into account the possible effects of gender. The purpose of this study was to estimate the association between SUA and arterial stiffness in general population and hypertensivepatients, as a whole population and as divided by gender, by pooling results from existing studies.Materials and methods: Carotid-femoral and brachial-ankle PWV (cf- and ba-PWV) have been analyzed separately and subgroup analyses by gender are reported. Among 692 potentially relevant works, 24 articles were analyzed. Results: Seven studies referred to cf-PWV in the general population with an overall positive association at adjusted analysis for both males and females (beta regression coefficient (ß): 0.07; 95%CI: 0.03; 0.11 and ß: 0.06; 95%CI: 0.03; 0.09, respectively). Twelve studies referred to ba-PWV in the general population with the finding of a positive association at adjusted analysis for females (ß: 0.04; 95% confidence interval (CI): 0.01;0.07), but not for males (ß: 0.13; 95%CI: -0.09; 0.34). In hypertensivepatients only four studies evaluated cf-PWV and one ba-PWV with only one study (with cf-PWV) finding positive association. Conclusion: The association between SUA and cf-PWV resulted significant in general population in both males and females while it was only significant for female regarding ba-PWV. Furthermore, the few available studies found no significant relationship between SUA and both cf- and ba-PWV in hypertensive subjects.
Authors: Min Tao; Xiaoyan Ma; Xiaoling Pi; Yingfeng Shi; Lunxian Tang; Yan Hu; Hui Chen; Xun Zhou; Lin Du; Yongbin Chi; Shougang Zhuang; Na Liu Journal: BMJ Open Date: 2021-09-16 Impact factor: 3.006
Authors: Humam Hamid; Venla Kurra; Manoj Kumar Choudhary; Heidi Bouquin; Onni Niemelä; Mika A P Kähönen; Jukka T Mustonen; Ilkka H Pörsti; Jenni K Koskela Journal: BMC Cardiovasc Disord Date: 2021-05-26 Impact factor: 2.298
Authors: John B Kostis; Chun Pang Lin; Jeanne M Dobrzynski; William J Kostis; Matthew Ambrosio; Javier Cabrera Journal: Int J Cardiol Cardiovasc Risk Prev Date: 2021-10-28
Authors: Simonetta Genovesi; Laura Montelisciani; Francesca Viazzi; Marco Giussani; Giulia Lieti; Ilenia Patti; Antonina Orlando; Laura Antolini; Paolo Salvi; Gianfranco Parati Journal: Front Cardiovasc Med Date: 2022-08-11