Background & objectives: Chikungunya (CHIK) is a neglected, re-emerging arboviral disease. Limited information on CHIK-confirmed cases during interepidemic period is available from India. This surveillance study was conducted in Madhya Pradesh (MP), India, during the years 2016-2017, to provide information about CHIK cases. Methods: Blood samples collected from patients suspected having CHIK were tested by immunoglobulin (Ig) IgM ELISA or real time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of CHIK virus (CHIKV)-specific IgM antibodies or viral RNA, respectively. Partial envelope-1 gene sequencing was done. Clinical and demographic data were collected and analyzed. Results: Of the 4019 samples tested, 494 (12.2%) were found positive for CHIKV infection. The positivity was detected in both rural and urban areas. The mean age of CHIK-positive cases was 33.12±18.25 yr. Headache and joint pain were the most prominent symptoms, 34.6 per cent (171/494) of the CHIK cases required hospitalization and six patients with CHIKV infection died. The East/Central/South African genotype of CHIKV was found to be circulating in the study area. Interpretation & conclusions: Our study recorded a higher CHIK positivity during 2016-2017 in comparison to earlier reports from MP, India. A high proportion of CHIK cases required hospitalization and deaths were also reported, which indicated the severity of the disease in the study area. In-depth molecular analysis of the virus and other risk factors is essential to understand the trends in disease severity.
Background & objectives: Chikungunya (CHIK) is a neglected, re-emerging arboviral disease. Limited information on CHIK-confirmed cases during interepidemic period is available from India. This surveillance study was conducted in Madhya Pradesh (MP), India, during the years 2016-2017, to provide information about CHIK cases. Methods: Blood samples collected from patients suspected having CHIK were tested by immunoglobulin (Ig) IgM ELISA or real time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of CHIK virus (CHIKV)-specific IgM antibodies or viral RNA, respectively. Partial envelope-1 gene sequencing was done. Clinical and demographic data were collected and analyzed. Results: Of the 4019 samples tested, 494 (12.2%) were found positive for CHIKV infection. The positivity was detected in both rural and urban areas. The mean age of CHIK-positive cases was 33.12±18.25 yr. Headache and joint pain were the most prominent symptoms, 34.6 per cent (171/494) of the CHIK cases required hospitalization and six patients with CHIKV infection died. The East/Central/South African genotype of CHIKV was found to be circulating in the study area. Interpretation & conclusions: Our study recorded a higher CHIK positivity during 2016-2017 in comparison to earlier reports from MP, India. A high proportion of CHIK cases required hospitalization and deaths were also reported, which indicated the severity of the disease in the study area. In-depth molecular analysis of the virus and other risk factors is essential to understand the trends in disease severity.
Authors: Manoj Murhekar; K Kanagasabai; Vishal Shete; Vasna Joshua; M Ravi; B K Kirubakaran; R Ramachandran; R Sabarinathan; Nivedita Gupta Journal: Trans R Soc Trop Med Hyg Date: 2019-05-01 Impact factor: 2.184
Authors: Anuja P Kawle; Amit R Nayak; Shradha S Bhullar; Smita R Borkar; Sanjeev D Patankar; Hatim F Daginawala; Lokendra R Singh; Rajpal S Kashyap Journal: J Vector Borne Dis Date: 2017 Jan-Mar Impact factor: 1.688
Authors: Pradip V Barde; Mohan K Shukla; Praveen K Bharti; Bhupesh K Kori; Jayant K Jatav; Neeru Singh Journal: WHO South East Asia J Public Health Date: 2014 Jan-Mar
Authors: Prasanna N Yergolkar; Babasaheb V Tandale; Vidya A Arankalle; Padmakar S Sathe; A B Sudeep; Swati S Gandhe; Mangesh D Gokhle; George P Jacob; Supriya L Hundekar; Akhilesh C Mishra Journal: Emerg Infect Dis Date: 2006-10 Impact factor: 6.883