Literature DB >> 32130609

Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation.

L F Zainullina1, T A Gudasheva1, Yu V Vakhitova2, S B Seredenin1.   

Abstract

The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10-7 М), which is comparable to that of endogenous neurotrophin (10-9 М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G1 phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.

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Year:  2020        PMID： 32130609     DOI： 10.1134/S1607672919060139

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  11 in total

1.  An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons.

Authors:  Lotta Agholme; Tobias Lindström; Katarina Kågedal; Jan Marcusson; Martin Hallbeck
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

2.  Brain-derived neurotrophic factor loop 4 dipeptide mimetic GSB-106 activates TrkB, Erk, and Akt and promotes neuronal survival in vitro.

Authors:  T A Gudasheva; I O Logvinov; T A Antipova; S B Seredenin
Journal:  Dokl Biochem Biophys       Date:  2013-08-23       Impact factor: 0.788

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Authors:  Alan H Nagahara; Mark H Tuszynski
Journal:  Nat Rev Drug Discov       Date:  2011-03       Impact factor: 84.694

Review 5.  Neurotrophin-regulated signalling pathways.

Authors:  Louis F Reichardt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-09-29       Impact factor: 6.237

6.  A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis.

Authors:  G Ochs; R D Penn; M York; R Giess; M Beck; J Tonn; J Haigh; E Malta; M Traub; M Sendtner; K V Toyka
Journal:  Amyotroph Lateral Scler Other Motor Neuron Disord       Date:  2000-06

7.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

8.  Dipeptide Mimetic of the Brain-derived Neurotrophic Factor Prevents Impairments of Neurogenesis in Stressed Mice.

Authors:  T A Gudasheva; P Yu Povarnina; S B Seredenin
Journal:  Bull Exp Biol Med       Date:  2017-02-27       Impact factor: 0.804

Review 9.  BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.

Authors:  Bai Lu; Guhan Nagappan; Xiaoming Guan; Pradeep J Nathan; Paul Wren
Journal:  Nat Rev Neurosci       Date:  2013-05-15       Impact factor: 34.870

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Authors:  J Y Koh; B J Gwag; D Lobner; D W Choi
Journal:  Science       Date:  1995-04-28       Impact factor: 47.728
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  3 in total

1.  Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression.

Authors:  L F Zainullina; Yu V Vakhitova; A Yu Lusta; T A Gudasheva; S B Seredenin
Journal:  Sci Rep       Date:  2021-04-08       Impact factor: 4.379

2.  Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling.

Authors:  Yulia V Vakhitova; Tatiana S Kalinina; Liana F Zainullina; Anastasiya Yu Lusta; Anna V Volkova; Nikita V Kudryashov; Tatiana A Gudasheva; Alexander A Shimshirt; Ilya A Kadnikov; Mikhail V Voronin; Sergei B Seredenin
Journal:  Int J Mol Sci       Date:  2021-12-13       Impact factor: 5.923

3.  The Effects of Serum Removal on Gene Expression and Morphological Plasticity Markers in Differentiated SH-SY5Y Cells.

Authors:  Alix C Thomson; Teresa Schuhmann; Tom A de Graaf; Alexander T Sack; Bart P F Rutten; Gunter Kenis
Journal:  Cell Mol Neurobiol       Date:  2021-03-03       Impact factor: 4.231
  3 in total

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