Literature DB >> 23674053

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.

Bai Lu1, Guhan Nagappan, Xiaoming Guan, Pradeep J Nathan, Paul Wren.   

Abstract

Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. This article reviews the key issues in translating BDNF biology into synaptic repair therapies.

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Year:  2013        PMID： 23674053     DOI： 10.1038/nrn3505

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  230 in total

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Journal:  Drug Discov Today       Date:  2011-12-29       Impact factor: 7.851

Review 2.  Synapses and memory storage.

Authors:  Mark Mayford; Steven A Siegelbaum; Eric R Kandel
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-06-01       Impact factor: 10.005

3.  Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.

Authors:  R D Terry; E Masliah; D P Salmon; N Butters; R DeTeresa; R Hill; L A Hansen; R Katzman
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422

4.  Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study.

Authors:  Deepa P Ramasamy; Murali Ramanathan; Jennifer L Cox; Ronald Antulov; Bianca Weinstock-Guttman; Niels Bergsland; Ralph H B Benedict; Michael G Dwyer; Alireza Minagar; Robert Zivadinov
Journal:  Pathophysiology       Date:  2010-05-15

Review 5.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

6.  Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.

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7.  Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity.

Authors:  A Veronica Witte; Julia Kürten; Stefanie Jansen; Anja Schirmacher; Eva Brand; Jens Sommer; Agnes Flöel
Journal:  J Neurosci       Date:  2012-03-28       Impact factor: 6.167

8.  Deoxygedunin, a natural product with potent neurotrophic activity in mice.

Authors:  Sung-Wuk Jang; Xia Liu; Chi Bun Chan; Stefan A France; Iqbal Sayeed; Wenxue Tang; Xi Lin; Ge Xiao; Raul Andero; Qiang Chang; Kerry J Ressler; Keqiang Ye
Journal:  PLoS One       Date:  2010-07-13       Impact factor: 3.240

9.  CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.

Authors:  Barbara L Apostol; Danielle A Simmons; Chiara Zuccato; Katalin Illes; Judit Pallos; Malcolm Casale; Paola Conforti; Catarina Ramos; Margaret Roarke; Satish Kathuria; Elena Cattaneo; J Lawrence Marsh; Leslie Michels Thompson
Journal:  Mol Cell Neurosci       Date:  2008-04-24       Impact factor: 4.314

10.  Impact of brain-derived neurotrophic factor Val66Met polymorphism on cortical thickness and voxel-based morphometry in healthy Chinese young adults.

Authors:  Xuejuan Yang; Peng Liu; Jinbo Sun; Guihong Wang; Fang Zeng; Kai Yuan; Jixin Liu; Minghao Dong; Karen M von Deneen; Wei Qin; Jie Tian
Journal:  PLoS One       Date:  2012-06-13       Impact factor: 3.240
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  237 in total

1.  L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.

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Journal:  CNS Neurosci Ther       Date:  2016-07-20       Impact factor: 5.243

2.  7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Authors:  Zhentao Zhang; Xia Liu; Jason P Schroeder; Chi-Bun Chan; Mingke Song; Shan Ping Yu; David Weinshenker; Keqiang Ye
Journal:  Neuropsychopharmacology       Date:  2013-09-11       Impact factor: 7.853

Review 3.  Synaptic optical imaging platforms: Examining pharmacological modulation of neurotransmitter release at discrete synapses.

Authors:  Paolomi Merchant; David Sulzer; Dalibor Sames
Journal:  Neuropharmacology       Date:  2015-03-30       Impact factor: 5.250

4.  HIV-1 Protein Tat1-72 Impairs Neuronal Dendrites via Activation of PP1 and Regulation of the CREB/BDNF Pathway.

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Journal:  Virol Sin       Date:  2018-05-08       Impact factor: 4.327

5.  BDNF in the Aged Brain: Translational Implications for Parkinson's Disease.

Authors:  N M Mercado; T J Collier; C E Sortwell; K Steece-Collier
Journal:  Austin Neurol Neurosci       Date:  2017-09-19

6.  BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.

Authors:  Michael J Van Kanegan; Dong Ning He; Denise E Dunn; Peiying Yang; Robert A Newman; Anne E West; Donald C Lo
Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

7.  Tumor necrosis factor (TNF) modulates synaptic plasticity in a concentration-dependent manner through intracellular calcium stores.

Authors:  Nicola Maggio; Andreas Vlachos
Journal:  J Mol Med (Berl)       Date:  2018-08-02       Impact factor: 4.599

8.  BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.

Authors:  Yen Ying Lim; Jason Hassenstab; Carlos Cruchaga; Alison Goate; Anne M Fagan; Tammie L S Benzinger; Paul Maruff; Peter J Snyder; Colin L Masters; Ricardo Allegri; Jasmeer Chhatwal; Martin R Farlow; Neill R Graff-Radford; Christoph Laske; Johannes Levin; Eric McDade; John M Ringman; Martin Rossor; Stephen Salloway; Peter R Schofield; David M Holtzman; John C Morris; Randall J Bateman
Journal:  Brain       Date:  2016-08-12       Impact factor: 13.501

9.  Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis.

Authors:  Arian Madani Neishaboori; Solmaz Nasseri Maleki; Mahdi Saberi Pirouz; Sara Golmohammadi; Donya Nazarinia; Nahid Aboutaleb
Journal:  Inflammopharmacology       Date:  2020-11-17       Impact factor: 4.473

10.  Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV-Infected Patients.

Authors:  Ferdous Kadri; Andrea LaPlante; Mariacristina De Luca; Lisa Doyle; Cruz Velasco-Gonzalez; Jonathan R Patterson; Patricia E Molina; Steve Nelson; Arnold H Zea; Christopher H Parsons; Francesca Peruzzi
Journal:  J Cell Physiol       Date:  2016-04       Impact factor: 6.384
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