| Literature DB >> 32128023 |
Ignacio J Ansotegui1, Giovanni Melioli2, Giorgio Walter Canonica3, Luis Caraballo4, Elisa Villa5, Motohiro Ebisawa6, Giovanni Passalacqua7, Eleonora Savi8, Didier Ebo9, R Maximiliano Gómez10, Olga Luengo Sánchez11, John J Oppenheimer12, Erika Jensen-Jarolim13, David A Fischer14, Tari Haahtela15, Martti Antila16, Jean J Bousquet17,18,19,20,21, Victoria Cardona22, Wen Chin Chiang23, Pascal M Demoly24,25, Lawrence M DuBuske26, Marta Ferrer Puga27, Roy Gerth van Wijk28, Sandra Nora González Díaz29, Alexei Gonzalez-Estrada30, Edgardo Jares31, Ayse Füsun Kalpaklioğlu32, Luciana Kase Tanno33, Marek L Kowalski34, Dennis K Ledford35, Olga Patricia Monge Ortega36, Mário Morais Almeida37, Oliver Pfaar38, Lars K Poulsen39, Ruby Pawankar40, Harald E Renz41, Antonino G Romano42, Nelson A Rosário Filho43, Lanny Rosenwasser44, Mario A Sánchez Borges45, Enrico Scala46, Gian-Enrico Senna47, Juan Carlos Sisul48, Mimi L K Tang49, Bernard Yu-Hor Thong50, Rudolf Valenta51,52,53, Robert A Wood54, Torsten Zuberbier55.
Abstract
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.Entities:
Keywords: AAAAI, American Academy of Allergy Asthma and Immunology; ABA, Allergen Bead Array; ACAAI, American College of Allergy Asthma and Immunology; AEC, Allergen Exposure Chambers; AIT, allergen immunotherapy; AP, Alkaline Phosphatase; AU/mL, Allergenic Units milliLiter; Allergy; Anti-IgE, Antibody against IgE; BAT, Basophil Activation Test; BAU/mL, Biologic Allergenic Units milliLiter; CBA, Cytometric Bead Array; CCD, Cross-reactive Carbohydrate Determinants; CDER, Center for Drug Evaluation and Research (USA); CL, Chemiluminescence; CaFE, Calibrated Fluorescence Enhancement; DBPCFC, Double-Blind Placebo-Controlled Food Challenge; Diagnostic strategies; EAACI, European Academy of Allergy and Immunology; EIA, Enzyme Immune Assay; ELISA, Enzyme Linked Immuno Sorbent Analysis; EMEA, European MEdicine Agencies; ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3; FACS, Fluorescence-Activated Cell Sorting; FDA, Food and Drug Administration (U.S. Department of Health and Human Services); FEIA, Fluorescent Enzyme Immunoassays; FcεRI, High affinity IgE receptor; H1, Histamine 1 receptor; H2, Histamine 2 receptor; HPO, Horseradish Peroxidase; IDT, Intradermal Test; ISAC, Immuno-Solid phase Allergen Chip; IUIS, International Union of Immunological Societies; IVD, in vitro diagnostic tool; IgE; IgE, immunoglobulin E; In vitro tests; LAMP-3, Lysosomal-Associated Membrane Protein; MBAD, Molecule Based Allergy Diagnostics; MRGPRX2, Mas-related G protein receptor 2; NIH, National Institutes of Health (USA); NMBAs, NeuroMuscular Blocking Agents; NPA, Negative Percent Agreement; NSAIDs, Non-Steroidal Anti-Inflammatory Drugs; PPA, Positive Percent Agreement; PPT, Prick-Prick Test; RAST, Radio Allergo Sorbent Test; SCAR, severe cutaneous adverse drug reactions; SPT, Skin prick test; Skin tests; kUA/L, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays; mAb, Monoclonal Antibody; pNPP, p-Nitrophenylphosphate; sIgE, specific IgE; w/v, weight /volume
Year: 2020 PMID： 32128023 PMCID： PMC7044795 DOI： 10.1016/j.waojou.2019.100080
Source DB: PubMed Journal: World Allergy Organ J ISSN： 1939-4551 Impact factor: 4.084