Mukesh Verma1, Divya Verma1, Rafeul Alam1,2. 1. Division of Allergy & Immunology, Department of Medicine, National Jewish Health. 2. University of Colorado Denver, School of Medicine, Denver, Colorado, USA.
Abstract
PURPOSE OF REVIEW: The purpose of this review is to provide a synthesis of recent discoveries about type-2 innate lymphoid cells, especially, as they relate to the pathogenesis of asthma. RECENT FINDINGS: We focused on features and characteristics of type-2 innate lymphoid cells (ILC2s) that distinguish them from other type-2 cells, especially Th2 cells. We collected and reviewed data related to human asthma and airway ILC2s. We examined the concept of ILC2 memory and trained immunity. We also analyzed steroid resistance of ILC2s, which is relevant for steroid-resistant asthma. SUMMARY: The implications of the findings include an understanding of ILC2 inflammation, and pathways and molecules that can be targeted by biologics and other therapeutic agents for management severe and steroid-resistant asthma.
PURPOSE OF REVIEW: The purpose of this review is to provide a synthesis of recent discoveries about type-2 innate lymphoid cells, especially, as they relate to the pathogenesis of asthma. RECENT FINDINGS: We focused on features and characteristics of type-2 innate lymphoid cells (ILC2s) that distinguish them from other type-2 cells, especially Th2 cells. We collected and reviewed data related to human asthma and airway ILC2s. We examined the concept of ILC2 memory and trained immunity. We also analyzed steroid resistance of ILC2s, which is relevant for steroid-resistant asthma. SUMMARY: The implications of the findings include an understanding of ILC2 inflammation, and pathways and molecules that can be targeted by biologics and other therapeutic agents for management severe and steroid-resistant asthma.
Authors: Steven G Kelsen; Ioana O Agache; Weily Soong; Elliot Israel; Geoffrey L Chupp; Dorothy S Cheung; Wiebke Theess; Xiaoying Yang; Tracy L Staton; David F Choy; Alice Fong; Ajit Dash; Michael Dolton; Rajita Pappu; Christopher E Brightling Journal: J Allergy Clin Immunol Date: 2021-04-16 Impact factor: 10.793
Authors: Norbert Krug; Jens M Hohlfeld; Anne-Marie Kirsten; Oliver Kornmann; Kai M Beeh; Dominik Kappeler; Stephanie Korn; Stanislav Ignatenko; Wolfgang Timmer; Cordelia Rogon; Jana Zeitvogel; Nan Zhang; Joachim Bille; Ursula Homburg; Agnieszka Turowska; Claus Bachert; Thomas Werfel; Roland Buhl; Jonas Renz; Holger Garn; Harald Renz Journal: N Engl J Med Date: 2015-05-17 Impact factor: 91.245
Authors: Saya Moriyama; Jonathan R Brestoff; Anne-Laure Flamar; Jesper B Moeller; Christoph S N Klose; Lucille C Rankin; Naomi A Yudanin; Laurel A Monticelli; Gregory Garbès Putzel; Hans-Reimer Rodewald; David Artis Journal: Science Date: 2018-03-02 Impact factor: 47.728
Authors: Kentaro Machida; Michael Aw; Brittany Ma Salter; Xiaotian Ju; Manali Mukherjee; Gail M Gauvreau; Paul M O'Byrne; Parameswaran Nair; Roma Sehmi Journal: Am J Respir Crit Care Med Date: 2020-06-25 Impact factor: 21.405
Authors: Mihai G Netea; Leo A B Joosten; Eicke Latz; Kingston H G Mills; Gioacchino Natoli; Hendrik G Stunnenberg; Luke A J O'Neill; Ramnik J Xavier Journal: Science Date: 2016-04-21 Impact factor: 47.728
Authors: Laurel A Monticelli; Gregory F Sonnenberg; Michael C Abt; Theresa Alenghat; Carly G K Ziegler; Travis A Doering; Jill M Angelosanto; Brian J Laidlaw; Cliff Y Yang; Taheri Sathaliyawala; Masaru Kubota; Damian Turner; Joshua M Diamond; Ananda W Goldrath; Donna L Farber; Ronald G Collman; E John Wherry; David Artis Journal: Nat Immunol Date: 2011-11 Impact factor: 25.606
Authors: Pengfei Sui; Darin L Wiesner; Jinhao Xu; Yan Zhang; Jinwoo Lee; Steven Van Dyken; Amber Lashua; Chuyue Yu; Bruce S Klein; Richard M Locksley; Gail Deutsch; Xin Sun Journal: Science Date: 2018-03-29 Impact factor: 63.714
Authors: Christopher J Oliphant; You Yi Hwang; Jennifer A Walker; Maryam Salimi; See Heng Wong; James M Brewer; Alexandros Englezakis; Jillian L Barlow; Emily Hams; Seth T Scanlon; Graham S Ogg; Padraic G Fallon; Andrew N J McKenzie Journal: Immunity Date: 2014-07-31 Impact factor: 31.745