Literature DB >> 32122889

ISEcp1-Mediated Transposition Leads to Fosfomycin and Broad-Spectrum Cephalosporin Resistance in Klebsiella pneumoniae.

Nicolas Kieffer1, Laurent Poirel2,3,4, Linda Mueller1,4, Stefano Mancini1,5, Patrice Nordmann1,3,4,6.   

Abstract

A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella pneumoniae isolate was recovered, and whole-genome sequencing revealed ISEcp1-bla CTX-M-14b tandemly inserted upstream of the chromosomally encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and fosA genes showed that this insertion brought a strong hybrid promoter leading to overexpression of the fosA gene, resulting in fosfomycin resistance. This work showed the concomitant acquisition of resistance to broad-spectrum cephalosporins and fosfomycin due to a single genetic event.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  FOS; FosA; ISEcp1zzm321990; Klebsiella pneumoniae; fosfomycin

Mesh：

Substances：

Year:  2020        PMID： 32122889      PMCID： PMC7179579          DOI： 10.1128/AAC.00150-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  ISEcp1B-mediated transposition of blaCTX-M in Escherichia coli.

Authors:  Laurent Poirel; Marie-Frédérique Lartigue; Jean-Winoc Decousser; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

2.  Potential in vivo transfer of a blaCTX-M14-harbouring plasmid established by combining long- and short-read sequencing.

Authors:  Basil Britto Xavier; Gesuele Renzi; Christine Lammens; Abdessalam Cherkaoui; Herman Goossens; Jacques Schrenzel; Stephan Harbarth; Surbhi Malhotra-Kumar
Journal:  J Microbiol Methods       Date:  2019-02-07       Impact factor: 2.363

Review 3.  The impact of insertion sequences on bacterial genome plasticity and adaptability.

Authors:  Joachim Vandecraen; Michael Chandler; Abram Aertsen; Rob Van Houdt
Journal:  Crit Rev Microbiol       Date:  2017-04-13       Impact factor: 7.624

4.  Functional promoters created by the insertion of transposable element IS1.

Authors:  P Prentki; B Teter; M Chandler; D J Galas
Journal:  J Mol Biol       Date:  1986-10-05       Impact factor: 5.469

5.  Identification of FosA8, a Plasmid-Encoded Fosfomycin Resistance Determinant from Escherichia coli, and Its Origin in Leclercia adecarboxylata.

Authors:  Laurent Poirel; Xavier Vuillemin; Nicolas Kieffer; Linda Mueller; Marie-Christine Descombes; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191

6.  Distribution of virulence factors in ESBL-producing Escherichia coli isolated from the environment, livestock, food and humans.

Authors:  Andrea Müller; Roger Stephan; Magdalena Nüesch-Inderbinen
Journal:  Sci Total Environ       Date:  2015-10-02       Impact factor: 7.963

7.  Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae.

Authors:  Aurélie Jayol; Patrice Nordmann; Marine Desroches; Jean-Winoc Decousser; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

8.  Inhibition of Fosfomycin Resistance Protein FosA by Phosphonoformate (Foscarnet) in Multidrug-Resistant Gram-Negative Pathogens.

Authors:  Ryota Ito; Adam D Tomich; Christi L McElheny; Roberta T Mettus; Nicolas Sluis-Cremer; Yohei Doi
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191

9.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790

10.  Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene.

Authors:  Ryota Ito; Mustapha M Mustapha; Adam D Tomich; Jake D Callaghan; Christi L McElheny; Roberta T Mettus; Robert M Q Shanks; Nicolas Sluis-Cremer; Yohei Doi
Journal:  mBio       Date:  2017-08-29       Impact factor: 7.867
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  3 in total

1.  Selective Culture Medium for Screening of Fosfomycin Resistance in Enterobacterales.

Authors:  Patrice Nordmann; Mustafa Sadek; José Manuel Ortiz de la Rosa; Stefan Pfister; Claudine Fournier; Laurent Poirel
Journal:  J Clin Microbiol       Date:  2021-10-20       Impact factor: 11.677

2.  Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Strain Lacking the Hypermucoviscous Regulators (rmpA/rmpA2).

Authors:  Hisham N Altayb; Hana S Elbadawi; Othman Baothman; Imran Kazmi; Faisal A Alzahrani; Muhammad Shahid Nadeem; Salman Hosawi; Kamel Chaieb
Journal:  Antibiotics (Basel)       Date:  2022-04-28

3.  RamAp Is an Efflux Pump Regulator Carried by an IncHI2 Plasmid.

Authors:  Yu-Ping Hong; You-Wun Wang; Bo-Han Chen; Hui-Yung Song; Chien-Shun Chiou; Ying-Tsong Chen
Journal:  Antimicrob Agents Chemother       Date:  2021-10-25       Impact factor: 5.938
  3 in total

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