Yonggu Lee1, Sung Joo Cha2, Jung-Hwan Park3, Jeong-Hun Shin1, Young-Hyo Lim2, Hwan-Cheol Park1, Jinho Shin2, Chun Ki Kim4, Jin-Kyu Park2. 1. Division of Cardiology, Hanyang University Guri Hospital, Republic of Korea. 2. Division of Cardiology, Hanyang University Medical Center, Republic of Korea. 3. Division of Endocrinology and Metabolism, Hanyang University Medical Center, Republic of Korea. 4. Department of Medicine, Hanyang University College of Medicine, Republic of Korea.
Abstract
AIMS: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. METHODS: Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. RESULTS: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031). CONCLUSION: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
AIMS: Previous studies from Western countries have been unable to demonstrate a relationship between insulin resistance and new-onset atrial fibrillation. We aimed to evaluate this relationship in the nondiabetic Asian population. METHODS: Between 2001-2003, 8175 adults (mean age 51.5 years, 53% women) without both existing atrial fibrillation and diabetes and with insulin resistance measures at baseline were enrolled and were followed by biennial electrocardiograms thereafter until 2014. We constructed multivariable-adjusted Cox proportional hazard models for risk of incident atrial fibrillation. RESULTS: Over a median follow-up of 12.3 years, 136 participants (1.89/1000 person-years) developed atrial fibrillation. Higher homeostasis model assessment of insulin resistance (HOMA-IR) was independently associated with newly developed atrial fibrillation (hazard ratio 1.61, 95% confidence interval 1.14-2.28). Atrial fibrillation development increased at the HOMA-IR levels approximately between 1-2.5, and then plateaued afterwards (p = 0.031). CONCLUSION: There is a significant relationship between insulin resistance and atrial fibrillation development independent of other known risk factors, including obesity in a nondiabetic Asian population.
Authors: Alexander Zabala; Vladimer Darsalia; Marcus Lind; Ann-Marie Svensson; Stefan Franzén; Björn Eliasson; Cesare Patrone; Magnus Jonsson; Thomas Nyström Journal: Cardiovasc Diabetol Date: 2021-10-06 Impact factor: 9.951
Authors: Yonggu Lee; Jeong-Hun Shin; Byung Sik Kim; Hyungdon Kook; Woohyeun Kim; Ran Heo; Young-Hyo Lim; Jinho Shin; Chun Ki Kim; Jin-Kyu Park Journal: J Pers Med Date: 2022-07-21