An approach to natural insect repellent formulations: from basic research to technological development.

The incidence of dengue, Zika, chikungunya, yellow fever and malaria cases has increased significantly in the world. To avoid mosquito bites, one of the best strategies is the use of repellents. The interest in using plants as mosquito repellents has increased significantly. In this review, has been performed a bibliographic survey of the plants with repellent activity, evaluate the trends of natural repellent formulations in the scientific literature, those described in patents and commercially available products. Limonene, 1,8-cineole, geraniol, eugenol and citronellal are the active compounds that mostly appear in the essential oils of plants with repellent activity. The type of natural repellent formulation mostly widely marketed is the spray and lotion, respectively. In patents, classic formulation as emulsion was most frequently used, followed by lotions and sprays. Data collected from scientific articles and patents show that microparticles are the most widely used extended release systems nowadays for natural repellents. The citronella essential oil was the one mostly used among the classic commercially available formulations, as well as in the extended release systems described in the literature and patents. Future research must be conducted to the use of nanotechnology in the development of extended release systems containing essential oils with repellent activity produced from natural and biodegradable materials.