Zena Wehbe1, Suzanne A Nasser2, Ahmed El-Yazbi3,4, Salam Nasreddine5, Ali H Eid6,7. 1. Department of Biology, American University of Beirut, Beirut, Lebanon. 2. Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut, Lebanon. 3. Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Bliss Street, Riad El Solh, PO Box 11-0236, Beirut, 1107-2020, Lebanon. 4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. 5. Biology Department, Faculty of Sciences-Section I, Groupe Anti-cancer therapeutic approaches (ATAC), Laboratory Rammal Rammal, Lebanese University, Beirut, Lebanon. 6. Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Bliss Street, Riad El Solh, PO Box 11-0236, Beirut, 1107-2020, Lebanon. ae81@aub.edu.lb. 7. Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar. ae81@aub.edu.lb.
Abstract
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is a non-subsiding disease that remains a leading cause of morbidity and mortality. CVD has been associated with endocrine disruptors, such as bisphenol A (BPA). This review critically summarizes existing findings on BPA and hypertension, with particular attention to genomic, non-genomic, molecular, and cellular mechanisms of action that render BPA as a cardiovascular estrogenic disruptor. RECENT FINDINGS: Owing to its similar estrogenic structure, BPA has been shown to affect various phenotypes that are regulated by the natural hormone, estrogen. Indeed, BPA has been shown to interact with estrogen receptors, located both in the cell membrane and in the cytoplasm/nucleus. Given that estrogen plays an important role in cardiovascular physiology, a contributing role for BPA in CVD would not be unexpected. Existing literature, though limited, established BPA as a source of disruption in cardiovascular health, particularly hypertension. However, effects of BPA are largely dependent on the dose, patient gender, tissue, and developmental stage of the exposed tissue/organ. Accumulating evidence argues for an adverse effect of BPA on blood pressure, with this effect being gender, dose, and time specific. Thus, comprehensive studies which take these factors and other parameters, like epigenetic factors, into account are warranted before a thorough understanding is at hand.
PURPOSE OF REVIEW: Cardiovascular disease (CVD) is a non-subsiding disease that remains a leading cause of morbidity and mortality. CVD has been associated with endocrine disruptors, such as bisphenol A (BPA). This review critically summarizes existing findings on BPA and hypertension, with particular attention to genomic, non-genomic, molecular, and cellular mechanisms of action that render BPA as a cardiovascular estrogenic disruptor. RECENT FINDINGS: Owing to its similar estrogenic structure, BPA has been shown to affect various phenotypes that are regulated by the natural hormone, estrogen. Indeed, BPA has been shown to interact with estrogen receptors, located both in the cell membrane and in the cytoplasm/nucleus. Given that estrogen plays an important role in cardiovascular physiology, a contributing role for BPA in CVD would not be unexpected. Existing literature, though limited, established BPA as a source of disruption in cardiovascular health, particularly hypertension. However, effects of BPA are largely dependent on the dose, patient gender, tissue, and developmental stage of the exposed tissue/organ. Accumulating evidence argues for an adverse effect of BPA on blood pressure, with this effect being gender, dose, and time specific. Thus, comprehensive studies which take these factors and other parameters, like epigenetic factors, into account are warranted before a thorough understanding is at hand.
Authors: Weili Yang; Joseph M Braun; Ann M Vuong; Zana Percy; Yingying Xu; Changchun Xie; Ranjan Deka; Antonia M Calafat; Maria Ospina; Erika Werner; Kimberly Yolton; Kim M Cecil; Bruce P Lanphear; Aimin Chen Journal: Environ Res Date: 2021-10-15 Impact factor: 6.498
Authors: Adnan Badran; Suzanne A Nasser; Joelle Mesmar; Ahmed F El-Yazbi; Alessandra Bitto; Manal M Fardoun; Elias Baydoun; Ali H Eid Journal: Int J Mol Sci Date: 2020-11-20 Impact factor: 5.923
Authors: Ilaria Cimmino; Francesca Fiory; Giuseppe Perruolo; Claudia Miele; Francesco Beguinot; Pietro Formisano; Francesco Oriente Journal: Int J Mol Sci Date: 2020-08-11 Impact factor: 5.923