Literature DB >> 32114452

Role of natural compounds in preventing and treating breast cancer.

Brianna Noel1, Santosh Kumar Singh2, James W Lillard1, Rajesh Singh3.   

Abstract

Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with drug resistance, cancer relapse, and side effects, scientists are turning to agents with more efficacy, such as natural compounds for treatment and prevention of BrCa. Selected natural compounds, substances derived from living organisms, promote apoptosis and inhibit metastasis, preventing cancer growth. As a result, these compounds have the potential to suppress BrCa progression, thus increasing patient survival rates and decreasing the number of BrCa-related deaths. In this review, we summarize natural compounds that have displayed, anti-cancer effects on BrCa cells in various studies. These natural compounds inhibit the development of BrCa, suppress the growth of cancer cells, and promote cell death. We conclude that natural compounds are efficient, effective and promising agents for treating BrCa other than therapeutic methods.

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Year:  2020        PMID: 32114452      PMCID: PMC7326582          DOI: 10.2741/S544

Source DB:  PubMed          Journal:  Front Biosci (Schol Ed)        ISSN: 1945-0516


  116 in total

1.  Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells.

Authors:  Aamir Ahmad; Sanila H Sarkar; Bassam Bitar; Shadan Ali; Amro Aboukameel; Seema Sethi; Yiwei Li; Bin Bao; Dejuan Kong; Sanjeev Banerjee; Subhash B Padhye; Fazlul H Sarkar
Journal:  Mol Cancer Ther       Date:  2012-07-19       Impact factor: 6.261

2.  Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.

Authors:  Bharat B Aggarwal; Shishir Shishodia; Yasunari Takada; Sanjeev Banerjee; Robert A Newman; Carlos E Bueso-Ramos; Janet E Price
Journal:  Clin Cancer Res       Date:  2005-10-15       Impact factor: 12.531

3.  Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.

Authors:  Bin Chen; Youzhi Zhang; Yang Wang; Jun Rao; Xiaomei Jiang; Zihui Xu
Journal:  J Steroid Biochem Mol Biol       Date:  2014-01-30       Impact factor: 4.292

4.  Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer.

Authors:  Fadwa Odeh; Said I Ismail; Rana Abu-Dahab; Ismail S Mahmoud; Abeer Al Bawab
Journal:  Drug Deliv       Date:  2012-10-08       Impact factor: 6.419

5.  Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.

Authors:  Avalon Garcia; Yang Zheng; Chen Zhao; Alfredo Toschi; Judy Fan; Natalie Shraibman; H Alex Brown; Dafna Bar-Sagi; David A Foster; Jack L Arbiser
Journal:  Clin Cancer Res       Date:  2008-07-01       Impact factor: 12.531

6.  Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway.

Authors:  Panhong Fan; Shujun Fan; Huan Wang; Jun Mao; Yu Shi; Mohammed M Ibrahim; Wei Ma; Xiaotang Yu; Zhenhuan Hou; Bo Wang; Lianhong Li
Journal:  Stem Cell Res Ther       Date:  2013       Impact factor: 6.832

7.  Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2-Akt axis.

Authors:  B S Vinod; H H Nair; V Vijayakurup; A Shabna; S Shah; A Krishna; K S Pillai; S Thankachan; R J Anto
Journal:  Cell Death Discov       Date:  2015-12-07

8.  Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells

Authors:  Zahra Javan Maasomi; Younes Pilehvar Soltanahmadi; Mehdi Dadashpour; Shahriar Alipour; Somayeh Abolhasani; Nosratollah Zarghami
Journal:  Asian Pac J Cancer Prev       Date:  2017-05-01

9.  TRAIL-Induced Apoptosis in TRAIL-Resistant Breast Carcinoma Through Quercetin Cotreatment.

Authors:  Jasmine M Manouchehri; Katherine A Turner; Michael Kalafatis
Journal:  Breast Cancer (Auckl)       Date:  2018-01-15

Review 10.  Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review.

Authors:  Gautam Sethi; Muthu K Shanmugam; Sudha Warrier; Myriam Merarchi; Frank Arfuso; Alan Prem Kumar; Anupam Bishayee
Journal:  Nutrients       Date:  2018-05-19       Impact factor: 5.717

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  7 in total

Review 1.  A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer.

Authors:  Muhammad Naeem; Muhammad Omer Iqbal; Humaira Khan; Muhammad Masood Ahmed; Muhammad Farooq; Muhammad Moeen Aadil; Mohamad Ikhwan Jamaludin; Abu Hazafa; Wan-Chi Tsai
Journal:  Molecules       Date:  2022-05-25       Impact factor: 4.927

Review 2.  Tocotrienols as an Anti-Breast Cancer Agent.

Authors:  Madison Trujillo; Anupreet Kharbanda; Christa Corley; Pilar Simmons; Antiño R Allen
Journal:  Antioxidants (Basel)       Date:  2021-08-29

Review 3.  Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling.

Authors:  Gilnei Bruno da Silva; Milena Ayumi Yamauchi; Daniela Zanini; Margarete Dulce Bagatini
Journal:  Purinergic Signal       Date:  2021-11-05       Impact factor: 3.765

Review 4.  Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint.

Authors:  Md Rezaul Islam; Fahadul Islam; Mohamed H Nafady; Muniya Akter; Saikat Mitra; Rajib Das; Humaira Urmee; Sheikh Shohag; Aklima Akter; Kumarappan Chidambaram; Fahad A Alhumaydhi; Talha Bin Emran; Simona Cavalu
Journal:  Molecules       Date:  2022-03-27       Impact factor: 4.411

Review 5.  Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis.

Authors:  Ravi Raj Pal; Vasundhara Rajpal; Priya Singh; Shubhini A Saraf
Journal:  Pharmaceutics       Date:  2021-05-22       Impact factor: 6.321

6.  Anti-proliferative activities of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) using ovarian cancer cell lines.

Authors:  Caroline E Ukwade; Osaretin A T Ebuehi; Rahmat A Adisa; Santosh K Singh; Rajesh Singh
Journal:  J Ovarian Res       Date:  2020-07-21       Impact factor: 4.234

7.  Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer.

Authors:  Santosh Kumar Singh; Jennifer B Gordetsky; Sejong Bae; Edward P Acosta; James W Lillard; Rajesh Singh
Journal:  Cells       Date:  2020-08-27       Impact factor: 6.600

  7 in total

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