Smita Asthana1, Vishal Busa1, Satyanarayana Labani2. 1. Scientist E, Division of Epidemiology and Biostatistics, National Institute of Cancer Prevention and Research, Indian Council of Medical Research, India. 2. Scientist E, Division of Epidemiology and Biostatistics, National Institute of Cancer Prevention and Research, Indian Council of Medical Research, India. Electronic address: satyanarayanalabani@yahoo.com.
Abstract
BACKGROUND: Role of Oral Contraceptive (OC) as a risk factor for cervical cancer remained controversial and unclear. OBJECTIVE: To evaluate risk of cervical cancer in OC users and non-users through a comprehensive systematic review. SEARCH STRATEGY: Literature search conducted in databases from January 1990 till August 2019 using various search terms. SELECTION CRITERIA: Primary research studies that evaluated and assessed the association of OC use with cervical cancer with study design of case control or cohort types published in English language. DATA COLLECTION AND ANALYSIS: PRISMA guided review was done by two independent researchers. Effect size estimated by pooled Odds ratio with 95 % Confidence Interval (CI) in random effect models on OC pill use for the risk of cervical cancer. RESULTS: Review included 19 studies. Overall risk of invasive cancer on OC use was found to be significant with unknown status of HPV OR (95 % CI) as 1.51 (1.35, 1.68) and for unknown HPV as 1.66 (1.24, 2.21). Adenocarcinoma, squamous cell carcinoma and carcinoma in situ had significant association with OR (95 % CI) of 1.77 (1.4, 2.24), 1.29 (1.18, 1.42) and 1.7 (1.18, 2.44) respectively. CONCLUSION: OC pills use had a definite associated risk for developing cervical cancer specially for Adenocarcinoma and longer duration of OC pills use.
BACKGROUND: Role of Oral Contraceptive (OC) as a risk factor for cervical cancer remained controversial and unclear. OBJECTIVE: To evaluate risk of cervical cancer in OC users and non-users through a comprehensive systematic review. SEARCH STRATEGY: Literature search conducted in databases from January 1990 till August 2019 using various search terms. SELECTION CRITERIA: Primary research studies that evaluated and assessed the association of OC use with cervical cancer with study design of case control or cohort types published in English language. DATA COLLECTION AND ANALYSIS: PRISMA guided review was done by two independent researchers. Effect size estimated by pooled Odds ratio with 95 % Confidence Interval (CI) in random effect models on OC pill use for the risk of cervical cancer. RESULTS: Review included 19 studies. Overall risk of invasive cancer on OC use was found to be significant with unknown status of HPV OR (95 % CI) as 1.51 (1.35, 1.68) and for unknown HPV as 1.66 (1.24, 2.21). Adenocarcinoma, squamous cell carcinoma and carcinoma in situ had significant association with OR (95 % CI) of 1.77 (1.4, 2.24), 1.29 (1.18, 1.42) and 1.7 (1.18, 2.44) respectively. CONCLUSION:OC pills use had a definite associated risk for developing cervical cancer specially for Adenocarcinoma and longer duration of OC pills use.
Authors: Rosa Drago-Ferrante; Riccardo Di Fiore; Fathi Karouia; Yashwanth Subbannayya; Saswati Das; Begum Aydogan Mathyk; Shehbeel Arif; Ana Paula Guevara-Cerdán; Allen Seylani; Aman Singh Galsinh; Weronika Kukulska; Joseph Borg; Sherif Suleiman; David Marshall Porterfield; Andrea Camera; Lane K Christenson; April Elizabeth Ronca; Jonathan G Steller; Afshin Beheshti; Jean Calleja-Agius Journal: Int J Mol Sci Date: 2022-07-05 Impact factor: 6.208
Authors: Leonardo Miranda Dos Santos; Josiellem Damasceno de Souza; Hilary Acha Mbakwa; Akim Felipe Santos Nobre; Rodrigo Covre Vieira; Stephen Francis Ferrari; Anderson Raiol Rodrigues; Edna Aoba Yassui Ishikawa; João Farias Guerreiro; Maísa Silva de Sousa Journal: PLoS One Date: 2022-07-18 Impact factor: 3.752
Authors: Erik Kudela; Alena Liskova; Marek Samec; Lenka Koklesova; Veronika Holubekova; Tomas Rokos; Erik Kozubik; Terezia Pribulova; Kevin Zhai; Dietrich Busselberg; Peter Kubatka; Kamil Biringer Journal: EPMA J Date: 2021-05-18 Impact factor: 8.836