Literature DB >> 3211180

Systemic toxicity of botulinum toxin by intramuscular injection in the monkey.

A B Scott1, D Suzuki.   

Abstract

Botulinum toxin (Oculinum) was injected intramuscularly into eight monkeys. The LD50 dose is estimated to be approximately 39 U/kg body weight. The lowest dose that caused systemic toxicity, 33 U/kg, was close to the fatal dose range, 38-42 U/kg.

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Year:  1988        PMID： 3211180     DOI： 10.1002/mds.870030409

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  24 in total

1.  Treatment of spasmodic torticollis with local injections of botulinum toxin. One-year follow-up in 37 patients.

Authors:  W Poewe; L Schelosky; B Kleedorfer; F Heinen; M Wagner; G Deuschl
Journal:  J Neurol       Date:  1992-01       Impact factor: 4.849

Review 2.  Botulinum A toxin for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms.

Authors:  Catherine A Thomas; Yao-Chi Chuang; Antonella Giannantoni; Michael B Chancellor
Journal:  Curr Urol Rep       Date:  2006-07       Impact factor: 3.092

Review 3.  Properties and use of botulinum toxin and other microbial neurotoxins in medicine.

Authors:  E J Schantz; E A Johnson
Journal:  Microbiol Rev       Date:  1992-03

Review 4.  Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.

Authors:  Marco Pirazzini; Ornella Rossetto; Roberto Eleopra; Cesare Montecucco
Journal:  Pharmacol Rev       Date:  2017-04       Impact factor: 25.468

5.  Neuronal delivery of antibodies has therapeutic effects in animal models of botulism.

Authors:  Patrick M McNutt; Edwin J Vazquez-Cintron; Luis Tenezaca; Celinia A Ondeck; Kyle E Kelly; Mark Mangkhalakhili; James B Machamer; Christopher A Angeles; Elliot J Glotfelty; Jaclyn Cika; Cesar H Benjumea; Justin T Whitfield; Philip A Band; Charles B Shoemaker; Konstantin Ichtchenko
Journal:  Sci Transl Med       Date:  2021-01-06       Impact factor: 17.956

6.  Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection.

Authors:  Sandeep Lakhtakia; Amitabh Monga; Rajesh Gupta; Rakesh Kalpala; Nitesh Pratap; Eric Wee; Saravanan Arjunan; D Nageshwar Reddy
Journal:  Indian J Gastroenterol       Date:  2011-12-17

Review 7.  New concepts in botulinum toxin therapy.

Authors:  G E Borodic; L B Pearce
Journal:  Drug Saf       Date:  1994-09       Impact factor: 5.606

Review 8.  Botulinum toxin A's expanding role in the management of pediatric lower urinary tract dysfunction.

Authors:  Tarek Hassouna; Joseph M Gleason; Armando J Lorenzo
Journal:  Curr Urol Rep       Date:  2014-08       Impact factor: 3.092

Review 9.  Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE).

Authors:  Brian J Hoare; Margaret A Wallen; Christine Imms; Elmer Villanueva; Hyam Barry Rawicki; Leeanne Carey
Journal:  Cochrane Database Syst Rev       Date:  2010-01-20

10.  Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents.

Authors:  Jerry O Conway; Laura J Sherwood; M Thelma Collazo; John A Garza; Andrew Hayhurst
Journal:  PLoS One       Date:  2010-01-21       Impact factor: 3.240
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