Makoto Sakai1, Makoto Sohda2, Hideyuki Saito1, Yasunari Ubukata1, Nobuhiro Nakazawa1, Kengo Kuriyama1, Keigo Hara1, Akihiko Sano1, Kyoichi Ogata1, Takehiko Yokobori3, Ken Shirabe4, Hiroshi Saeki1. 1. Division of Gastroenterological Surgery, Department of General Surgical Science, Graduate School of Medicine Gunma University, Gunma, Japan. 2. Division of Gastroenterological Surgery, Department of General Surgical Science, Graduate School of Medicine Gunma University, Gunma, Japan msohda@gunma-u.ac.jp. 3. Initiative for Advance Research, Gunma University, Gunma, Japan. 4. Department of General Surgical Science, Gunma University, Graduate School of Medicine, Gunma, Japan.
Abstract
BACKGROUND/AIM: Several immunoinflammatory and nutritional measures have been reported to be good prognostic indicators for esophageal cancer (EC). However, the association between those markers and the postoperative survival of EC patients remains unclear due to varying study designs and treatment strategies. The aim of this study was to compare the significance of preoperative immunoinflammatory and nutritional measures in patients with EC. PATIENTS AND METHODS: One hundred and five patients with EC who underwent McKeown esophagectomy with gastric tube reconstruction without neoadjuvant therapy between 2006 and 2014 were included in this study. The prognostic values of preoperative modified Glasgow prognostic score (mGPS), controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), C-reactive protein (CRP)-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were investigated using univariate and multivariate survival analyses. RESULTS: Multivariate analysis revealed that CAR and pathological stage are independent prognostic factors for overall survival (OS). CAR was significantly associated with more advanced pathological stage as both a subject and a continuous variable. CONCLUSION: Preoperative CAR was an independent prognostic factor for the OS of EC patients who underwent McKeown esophagectomy. The tumor-stage related increase in CAR demonstrated that a high CAR is associated with tumor progression in EC patients. Copyright
BACKGROUND/AIM: Several immunoinflammatory and nutritional measures have been reported to be good prognostic indicators for esophageal cancer (EC). However, the association between those markers and the postoperative survival of ECpatients remains unclear due to varying study designs and treatment strategies. The aim of this study was to compare the significance of preoperative immunoinflammatory and nutritional measures in patients with EC. PATIENTS AND METHODS: One hundred and five patients with EC who underwent McKeown esophagectomy with gastric tube reconstruction without neoadjuvant therapy between 2006 and 2014 were included in this study. The prognostic values of preoperative modified Glasgow prognostic score (mGPS), controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), C-reactive protein (CRP)-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were investigated using univariate and multivariate survival analyses. RESULTS: Multivariate analysis revealed that CAR and pathological stage are independent prognostic factors for overall survival (OS). CAR was significantly associated with more advanced pathological stage as both a subject and a continuous variable. CONCLUSION: Preoperative CAR was an independent prognostic factor for the OS of ECpatients who underwent McKeown esophagectomy. The tumor-stage related increase in CAR demonstrated that a high CAR is associated with tumor progression in ECpatients. Copyright
Authors: Valerie W Rusch; Thomas W Rice; John Crowley; Eugene H Blackstone; Ramon Rami-Porta; Peter Goldstraw Journal: J Thorac Cardiovasc Surg Date: 2010-04 Impact factor: 5.209