Issei Takeuchi1,2, Yuki Koshi1, Kimiko Makino3,2. 1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan. 2. Center for Drug Delivery Research, Tokyo University of Science, Chiba, Japan. 3. Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan makino@rs.noda.tus.ac.jp.
Abstract
BACKGROUND/AIM: Nanocomposite particles are suitable for inhalation; however, their systemic migration has not been confirmed. The aim of this study was to compare drug concentrations in lungs and blood after inhalation of nanocomposite particles. MATERIALS AND METHODS: Rifampicin (RFP) was used as a model drug. Nanocomposite particles were prepared from dichloromethane with RFP and poly(DL-lactic acid-co-glycolic acid) (PLGA) dissolved in an amino acid aqueous solution using a spray dryer. Measurement of RFP concentrations in lung and blood of mice was performed by in vivo tests. RESULTS: Compared with the oral administration group as a control, the RFP concentration in the lungs was significantly higher in the inhalation group. In addition, studies with a fluorescent substance suggested sustained release of drugs from nanocomposite particles in the lungs. CONCLUSION: Nanocomposite particles deliver pulmonary drug in an efficient and sustained manner. Copyright
BACKGROUND/AIM: Nanocomposite particles are suitable for inhalation; however, their systemic migration has not been confirmed. The aim of this study was to compare drug concentrations in lungs and blood after inhalation of nanocomposite particles. MATERIALS AND METHODS:Rifampicin (RFP) was used as a model drug. Nanocomposite particles were prepared from dichloromethane with RFP and poly(DL-lactic acid-co-glycolic acid) (PLGA) dissolved in an amino acid aqueous solution using a spray dryer. Measurement of RFP concentrations in lung and blood of mice was performed by in vivo tests. RESULTS: Compared with the oral administration group as a control, the RFP concentration in the lungs was significantly higher in the inhalation group. In addition, studies with a fluorescent substance suggested sustained release of drugs from nanocomposite particles in the lungs. CONCLUSION: Nanocomposite particles deliver pulmonary drug in an efficient and sustained manner. Copyright