Literature DB >> 32110255

Forensic Considerations in a Series of 14 Deaths of Patients with a Left Ventricular Assist Device.

Peter T Lin, Sarah Thomas.   

Abstract

INTRODUCTION: To better understand the forensic implications of death with a left ventricular assist device (LVAD), we reviewed all deaths that were reported to a regional medical examiner jurisdiction involving patients who had an LVAD.
METHODS: Medical examiner case files between January 2012 and September 2018 were searched for "LVAD" and "left ventricular assist device" to identify deaths that were reported to the medical examiner involving a decedent who had an LVAD at the time of death.
RESULTS: During the study period, a total of 14 deaths were reported to the regional medical examiner involving decedents who had an implanted LVAD at the time of death. The average age at death was 64 years, with a range from 40 to 81 years. The underlying cardiac disease leading to LVAD implantation was ischemic heart disease (n = 9), nonischemic dilated cardiomyopathy (n = 4), and chemotherapy-related cardiotoxicity (n = 1). Of these 14 deaths, 2 deaths were due to loss of power to the LVAD, 1 death was due to traumatic subdural hemorrhage occurring in the setting of anticoagulation therapy required by LVAD implantation, and 1 death was due to femur fracture following a fall. DISCUSSION: Medical examiners should be familiar with the potential complications of LVADs, especially those complications that may prompt consideration of non-natural manners of death. Medical examiners should also be aware of the tools and investigative strategies that may assist in the investigation of LVAD-related deaths.
© 2019 The Authors.

Entities:  

Keywords:  Autopsy; Cardiovascular pathology; Forensic pathology; LVAD; Left ventricular assist device

Year:  2020        PMID: 32110255      PMCID: PMC6997991          DOI: 10.1177/1925362119893459

Source DB:  PubMed          Journal:  Acad Forensic Pathol        ISSN: 1925-3621


  24 in total

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Authors:  Emma J Birks
Journal:  Tex Heart Inst J       Date:  2011

2.  Third INTERMACS Annual Report: the evolution of destination therapy in the United States.

Authors:  James K Kirklin; David C Naftel; Robert L Kormos; Lynne W Stevenson; Francis D Pagani; Marissa A Miller; Karen L Ulisney; J Timothy Baldwin; James B Young
Journal:  J Heart Lung Transplant       Date:  2011-02       Impact factor: 10.247

3.  The Fourth INTERMACS Annual Report: 4,000 implants and counting.

Authors:  James K Kirklin; David C Naftel; Robert L Kormos; Lynne W Stevenson; Francis D Pagani; Marissa A Miller; J Timothy Baldwin; James B Young
Journal:  J Heart Lung Transplant       Date:  2012-02       Impact factor: 10.247

Review 4.  Left Ventricular Assist Devices: A Rapidly Evolving Alternative to Transplant.

Authors:  Donna Mancini; Paolo C Colombo
Journal:  J Am Coll Cardiol       Date:  2015-06-16       Impact factor: 24.094

5.  Use of "therapeutic complication" as a manner of death.

Authors:  James R Gill; Lara B Goldfeder; Charles S Hirsch
Journal:  J Forensic Sci       Date:  2006-09       Impact factor: 1.832

6.  Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation.

Authors:  Nir Uriel; Sang-Woo Pak; Ulrich P Jorde; Brigitte Jude; Sophie Susen; Andre Vincentelli; Pierre-Vladimir Ennezat; Sarah Cappleman; Yoshifumi Naka; Donna Mancini
Journal:  J Am Coll Cardiol       Date:  2010-07-02       Impact factor: 24.094

Review 7.  Current state of ventricular assist devices.

Authors:  Marco Caccamo; Peter Eckman; Ranjit John
Journal:  Curr Heart Fail Rep       Date:  2011-06

Review 8.  The role of bridge to transplantation: should LVAD patients be transplanted?

Authors:  Emma J Birks; Magdi H Yacoub; Nicholas R Banner; Asghar Khaghani
Journal:  Curr Opin Cardiol       Date:  2004-03       Impact factor: 2.161

9.  Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients.

Authors:  James K Kirklin; David C Naftel; Robert L Kormos; Lynne W Stevenson; Francis D Pagani; Marissa A Miller; J T Baldwin; J Timothy Baldwin; James B Young
Journal:  J Heart Lung Transplant       Date:  2013-02       Impact factor: 10.247

Review 10.  Acquired von Willebrand syndrome associated with left ventricular assist device.

Authors:  Angelo Nascimbene; Sriram Neelamegham; O H Frazier; Joel L Moake; Jing-Fei Dong
Journal:  Blood       Date:  2016-05-03       Impact factor: 22.113

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