Literature DB >> 32109623

Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease.

Han Li1, Yuzhi Liu1, Danni Tian1, Lei Tian1, Xingke Ju1, Liang Qi1, Yongbo Wang1, Chengyuan Liang2.   

Abstract

Herein, 11 general types of natural cannabinoids from Cannabis sativa as well as 50 (-)-CBD analogues with therapeutic potential were described. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy and neurodegenerative diseases were comprehensively clarified. CBD indirectly acts as an endogenous cannabinoid receptor agonist to exert its neuroprotective effects. CBD also promotes neuroprotection through different signal transduction pathways mediated indirectly by cannabinoid receptors. Furthermore, CBD prevents the glycogen synthase kinase 3β (GSK-3β) hyperphosphorylation caused by Aβ and may be developed as a new therapeutic candidate for Alzheimer's disease.
Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease (AD); Cannabidiol (CBD); Cannabinoids; Cannabis; Epilepsy; Neurodegenerative disease

Year:  2020        PMID： 32109623     DOI： 10.1016/j.ejmech.2020.112163

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  14 in total

1.  Cannabinoid pharmacology and its therapeutic uses in Alzheimer's disease.

Authors:  Kadja Luana Chagas Monteiro; Marcone Gomes Dos Santos Alcântara; Thiago Mendonça de Aquino; Edeildo Ferreira da Silva-Júnior
Journal:  Neural Regen Res       Date:  2021-05       Impact factor: 5.135

2.  Neuroprotective constituents from the aerial parts of Cannabis sativa L. subsp. sativa.

Authors:  Jia Li; Guan Wang; Yu Qin; Xue Zhang; Hai-Feng Wang; Hong-Wei Liu; Ling-Juan Zhu; Xin-Sheng Yao
Journal:  RSC Adv       Date:  2020-08-28       Impact factor: 4.036

Review 3.  Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products.

Authors:  Dongchen An; Steve Peigneur; Louise Antonia Hendrickx; Jan Tytgat
Journal:  Int J Mol Sci       Date:  2020-07-17       Impact factor: 5.923

4.  Hemp seed (Cannabis sativa L.) enriched pasta: Physicochemical properties and quality evaluation.

Authors:  Dorota Teterycz; Aldona Sobota; Dominika Przygodzka; Paulina Łysakowska
Journal:  PLoS One       Date:  2021-03-18       Impact factor: 3.240

Review 5.  A Proteomic View of Cellular and Molecular Effects of Cannabis.

Authors:  Morteza Abyadeh; Vivek Gupta; Joao A Paulo; Veer Gupta; Nitin Chitranshi; Angela Godinez; Danit Saks; Mafruha Hasan; Ardeshir Amirkhani; Matthew McKay; Ghasem H Salekdeh; Paul A Haynes; Stuart L Graham; Mehdi Mirzaei
Journal:  Biomolecules       Date:  2021-09-27

6.  The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats.

Authors:  Mayila Tuerxun; Ajar Muhda; Lixin Yin
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

Review 7.  Cannabidiol: pharmacology and therapeutic targets.

Authors:  Stevie C Britch; Shanna Babalonis; Sharon L Walsh
Journal:  Psychopharmacology (Berl)       Date:  2020-11-21       Impact factor: 4.530

Review 8.  Molecular Targets of Cannabinoids Associated with Depression.

Authors:  Pradeep Paudel; Samir Ross; Xing-Cong Li
Journal:  Curr Med Chem       Date:  2022       Impact factor: 4.740

Review 9.  Cannabis and Canabidinoids on the Inflammatory Bowel Diseases: Going Beyond Misuse.

Authors:  Antonelly Cassio Alves de Carvalho; Gabriela Achete de Souza; Samylla Vaz de Marqui; Élen Landgraf Guiguer; Adriano Cressoni Araújo; Claudio José Rubira; Ricardo de Alvares Goulart; Uri Adrian Prync Flato; Patricia Cincotto Dos Santos Bueno; Rogério Leone Buchaim; Sandra M Barbalho
Journal:  Int J Mol Sci       Date:  2020-04-22       Impact factor: 5.923

Review 10.  Cannabidiol and Other Cannabinoids in Demyelinating Diseases.

Authors:  Carmen Navarrete; Adela García-Martín; Alain Rolland; Jim DeMesa; Eduardo Muñoz
Journal:  Int J Mol Sci       Date:  2021-03-15       Impact factor: 5.923
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