Literature DB >> 34165403

Molecular Targets of Cannabinoids Associated with Depression.

Pradeep Paudel1, Samir Ross1,2, Xing-Cong Li1,2.   

Abstract

Novel therapeutic strategies are needed to address depression, a major neurological disorder affecting hundreds of millions of people worldwide. Cannabinoids and their synthetic derivatives have demonstrated numerous neurological activities and may have the potential to be developed into new treatments for depression. This review highlights cannabinoid (CB) receptors, monoamine oxidase (MAO), N-methyl-D-aspartate (NMDA) receptor, gammaaminobutyric acid (GABA) receptor, and cholecystokinin (CCK) receptor as key molecular targets of cannabinoids that are associated with depression. The anti-depressant activity of cannabinoids and their binding modes with cannabinoid receptors are discussed, providing insights into rational design and discovery of new cannabinoids or cannabimimetic agents with improved druggable properties. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  CB receptors; CCK receptors; Cannabinoids; GABA receptors; MAO; NMDA receptors; depression; molecular targets

Mesh：

Substances：

Year:  2022        PMID： 34165403      PMCID： PMC9007087          DOI： 10.2174/0929867328666210623144658

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.740


  214 in total

1.  Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor.

Authors:  Shuang Han; Fei-Fei Zhang; Hai-Yan Qian; Li-Li Chen; Jian-Bin Pu; Xin Xie; Jian-Zhong Chen
Journal:  J Med Chem       Date:  2015-07-23       Impact factor: 7.446

2.  Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.

Authors:  J J Feigenbaum; F Bergmann; S A Richmond; R Mechoulam; V Nadler; Y Kloog; M Sokolovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

3.  Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase.

Authors:  B F Cravatt; K Demarest; M P Patricelli; M H Bracey; D K Giang; B R Martin; A H Lichtman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

4.  Identification of major depressive disorder and prediction of treatment response using functional connectivity between the prefrontal cortices and subgenual anterior cingulate: A real-world study.

Authors:  Qiang Wang; Shui Tian; Hao Tang; Xiaoxue Liu; Rui Yan; Lingling Hua; Jiabo Shi; Yu Chen; Rongxin Zhu; Qing Lu; Zhijian Yao
Journal:  J Affect Disord       Date:  2019-04-08       Impact factor: 4.839

5.  Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims.

Authors:  F Sherif; J Marcusson; L Oreland
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1991       Impact factor: 5.270

Review 6.  Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.

Authors:  M J Owens; C B Nemeroff
Journal:  Clin Chem       Date:  1994-02       Impact factor: 8.327

7.  The endocannabinoid/endovanilloid system and depression.

Authors:  Irena Smaga; Beata Bystrowska; Dawid Gawliński; Edmund Przegaliński; Małgorzata Filip
Journal:  Curr Neuropharmacol       Date:  2014-09       Impact factor: 7.363

8.  An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Authors:  R N Arey; J F Enwright; S M Spencer; E Falcon; A R Ozburn; S Ghose; C Tamminga; C A McClung
Journal:  Mol Psychiatry       Date:  2013-02-12       Impact factor: 15.992

9.  HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.

Authors:  Ana Vicente-Sánchez; Pilar Sánchez-Blázquez; María Rodríguez-Muñoz; Javier Garzón
Journal:  Mol Brain       Date:  2013-10-05       Impact factor: 4.041

10.  Cannabis in epilepsy: From clinical practice to basic research focusing on the possible role of cannabidivarin.

Authors:  Alessandra Morano; Pierangelo Cifelli; Paolo Nencini; Letizia Antonilli; Jinane Fattouch; Gabriele Ruffolo; Cristina Roseti; Eleonora Aronica; Cristina Limatola; Carlo Di Bonaventura; Eleonora Palma; Anna Teresa Giallonardo
Journal:  Epilepsia Open       Date:  2016-09-19
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  1 in total

Review 1.  Novel Molecular Targets of Antidepressants.

Authors:  Małgorzata Jarończyk; Jarosław Walory
Journal:  Molecules       Date:  2022-01-14       Impact factor: 4.411
  1 in total

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