| Literature DB >> 32106382 |
Zarrin Radbeh1, Narmela Asefi2, Hamed Hamishehkar3, Leila Roufegarinejad1, Akram Pezeshki4.
Abstract
Cornusmas' bioactive compounds are powerful antioxidants. In this study, we evaluated the antioxidant activity of the encapsulated bioactive compounds of Cornus mas extract (CME) and its release in semi digestive condition via enteric coated nanocarriers (NCs). The two forms of CME, encapsulated into enteric coated nanocarriers (CME-NCs) and free CME, were studied to determine the effect of encapsulation on the stability of antioxidants. Then, their effect on cell cycle, cell viability and apoptosis of cancer cells were studied. The characterization analysis reported the mean particle size and zeta potential value of NCs equal to 22.7 ± 6.58 nm and -16 ± 5 mV. The results showed that CME-NCs could improve IC50 value 1.33 and 1.47 times more than the free CME after 24 and 48 h of incubation. These findings confirmed that CME-NCs could stop the cells proliferation in G1 phase, and caused apoptosis in cancer cell line HT-29.Entities:
Keywords: Antioxidant activity; Bioactive compounds; Colorectal cancer; Cornus mas; Eudragit® S100; Nano-cubosomes
Mesh：
Substances：
Year: 2020 PMID： 32106382 DOI： 10.1016/j.biopha.2020.109906
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529