An Update on Health-Related Quality of Life and Patient-Reported Outcomes in Hidradenitis Suppurativa.

Hidradenitis suppurativa is a common inflammatory skin condition which causes recurrent abscesses, sinuses and scarring in the axillae, groin and inframammary areas. As well as causing significant physical distress due to pain and discharge, the condition impacts psychological well-being with markedly impaired quality of life. Patients suffer pain, embarrassment and psychological distress with impairment of their work and intimate relationships marking it as one of the most distressing dermatological conditions. Numerous studies have documented markers of psychological distress encompassing the physical effects such as pain and itch, affects on mood and impaired function.

Introduction

Adalimumab is a fully humanized monoclonal antibody to TNF-alpha and is licensed for the treatment of moderate to severe hidradenitis suppurativa. In two phase III studies; Pioneer I and II; patients who achieved a clinical response reported clinically meaningful improvement in Dermatology Life Quality Index (60.5% vs 30.4%), Pain Numeric Rating Scale (46.9% vs 19.9%), hidradenitis suppurativa quality of life (49.4% vs 26.9%), work-related performance (52.6% vs 37.7%), and non-work-related performance (59.5% vs 33.3%).

Hidradenitis Suppurativa (HS), is a chronic, recurrent and debilitating skin condition affecting the axilla and inguinal areas. Starting as painful nodules it can lead to abscess formation and scarring with significant disfigurement. It often produces a malodorous and recurrent discharge and can cause significant pain and distress particularly during a “flare up”. Hidradenitis suppurativa may have a severe impact on the quality of life of patients affected by it mainly due to the nature of the condition, the areas that it affects as well as the relative paucity of effective treatments. In Qualitative studies of patients with HS, feelings of shame, isolation and stigmatization are described, hence it is unsurprising that this condition significantly impacts quality of life.1,2 The location of lesions in genital areas can impact imtimate relationships while the pain of the condition as well as the unpredictability of flare-ups may affect a patient’s ability to work. In addition to clinical measurements of disease severity, it is important to assess impact on patient’s quality of life in Hidradenitis suppurativa. Although there is an increase in research in HS there is still a lack well-defined, robust patient-reported outcome measures and Quality of Life is not always measured. These deficits have been recognized in a recent position statement of the European Academy of Dermatology and Venereology.3

Health-Related Quality of Life

Health-related quality of life (HRQoL) is a multidimensional concept which refers to the perception of the overall effects of a disease and its impact on the patients’ daily functioning. Various instruments are used to measure HRQoL in dermatology. These include the Skindex-29 and Dermatology Life Quality Index, DLQI) and general (EQ-5D) HRQoL.

DLQI

The Dermatology Life Quality Index was developed by Finlay et al and is a self-administered 10-item questionnaire, designed to assess the impact of a particular skin condition in the previous week.4 Each question is graded 0–3, with 0 implying no impact and 3 indicating a major impact, the highest score possible is 30. The 10 questions are divided into 5 domains: symptoms, daily activities, leisure, work/school, personal relationships and impact of treatment. A total score of 2–5 indicates little effect, 6–10 a moderate effect, 11–20 a large effect and a score of 21–30 an extremely large effect on patient’s quality of life.5 The DLQI has limitations in that it is very much designed as a snap-shot at one timepoint and fails to compute cumulative life impairment. It is still the most widely used instrument and allows comparison across, different skin disease, different treatments and clinical trials.

Skindex-29

The Skindex-29 is a revised version of an earlier tool which contained 61 questions developed in 1996 and 1997 repsectively.6 It was deigned to allow capture of life impairment over time, a shortcoming of the DLQI. It is divided into three domains, symptoms (7 items), emotions (10 items) and functioning (12 items). Patients score how often (Never, Rarely, Sometimes, Often, All the time) over the previous four weeks the they experienced a feeling or symptom. Answers are converted to a linear scale 0–100 and generates three scale scores ie the average scores of items within a domain are combined into a domain score.

EQ-5D

The EuroQol-5D is a generic instrument developed by the European Quality of Group. It consists of a descriptive scale addressing: mobility, self-care, usual activities, pain/discomfort and anxiety/depression and a visual analog scale (VAS). Two versions currently exist: the EQ-5D-5L with five levels of severity for each question and the EQ-5D-3L with three levels of severity. EQ-5D scores range between –0.594 and 1.000 (full health). The instrument has been validated across several different diseases and a number of different languages.

Hospital-Based Studies of HR-Qol in Hidradenitis

The burden of HS has been investigated in several hospital-based studies, showing considerable impairment. In a study of 805 Danish patients attending an outpatient clinic, Jemec and colleagues found DLQI, Body Mass Index and smoking had a significant impact on EurQol VAS, Major Depression Inventory (MDI) and Euro-QoL-5D. Significant predictors for the model were DLQI (P < 0.05), BMI points above 25 and active smoking (both: P < 0.01) and MDI (P < 0.001). Van de Worth and Jemec found 110 patients attending a hospital-based setting to have a DLQI of 8.9 ± 8.37 In 211 patients attending a Dutch hospital clinic, patients with HS had significantly higher DLQI scores compared to dermatology control patients 8.4 ± 7.5 vs 4.3 ± 5.6 (P < 0.0001) and higher scores on the MDI Questionnaire 11.0 vs 7.2 (P < 0.0001).8 Kurek et al confirmed this finding in 90 patients attending a German Clinic where 38.6% of patients with HS reported depression versus 2.4% of age, sex and BMI-matched controls.9

In a cross-sectional study of 421 Danish patients with HS attending an outpatient dermatology department, patients had significantly decreased EQ-5D index and VAS scores in all age groups except for 65–74 year olds.10 The total index score in the cohort was 85% of that of the general population (0.705 compared with the population mean of 0.887) and the VAS score was 75% (62.25 compared with 82.6), indicating significant disability. Pain and discomfort had the most significant impact on the index. Vinding et al (16) found a mean EQ-5D index of 0.82 (95% confidence interval (CI): 0.74–0.90) and a mean VAS score of 79.56 (95% CI: 72.89–86.22). It is speculated that the participants had less severe disease than those in the present hospital-based study because they were drawn from the general population. This is supported by the greater disutility found by Matusiak et al, in which 54 hospital-based Polish patients with HS (28 women, 26 men) with a mean age of 39.94±11.63 years, completed the EQ-5D questionnaire.11 The authors found a mean±SD index and VAS score of 0.66±0.23 and 56.78±18.84, respectively.

In 94 Greek patients recruited at the dermatology department, the DLQI mean score was 11.43 ± 6.61 in patients with HS.12 The patients with HS presented statistically significantly higher anxiety (6.41 ± 3.31 vs 5.00 ± 1.59, p < 0.001), depression (5.45 ± 2.79 vs 4.16 ± 1.54, p < 0.001) as measured by the Hospital Anxiety and Depression Score (HADS), and loneliness and social isolation scores (42.86 ± 8.63 vs 35.57 ± 6.17, p < 0.001) as measured by the UCLA Loneliness Scale and lower self-esteem scores (18.91 ± 1.79 vs 19.77 ± 2.53, p = 0.008) as measured by the Rosenberg Self Esteem Scale, than healthy controls.

Hazvami et al analyzed HRQoL in five studies based in Pain VAS, DLQI, EuroQOL 5D VAS, Short Form-36, Total Work Productivity Impairment.13 Compared with patients with psoriasis, patients with HS reported higher scores for VAS-pain (54.3 vs 36.1 [P < 0.0001]), Dermatology Life Quality Index (15.3 vs 11.3 [P < 0.0001]), EuroQOL 5D VAS (58.8 vs 50.8 [P < 0.0002]), and Total Work Productivity Impairment (35.4 vs 18.2). Patients with HS had lower Short Form-36 Health Survey scores than did patients with psoriasis (physical, 39.6 vs 49.0; mental, 41.5 vs 47.5 [both P < 0.0001]).

In a two-centre study of 154 HS patients based in the US and Denmark, 35.7% of patients were depressed and average DLQI was 10, resilience as measured using the Brief Resilient Coping Scale, appeared to moderate depression in this study.14 Among 152 Greek patients with HS, the mean DLQI was 11.7 with patients with Hurley Stage III disease having significantly higher DLQI.15 In 52 Canadian patients with HS, those with higher self-reported malodour had significantly higher SkinDex scores but not DLQI scores. There was no difference in mean DLQI scores for the low- vs high-odour groups, but patients with high odour had a greater quality of life impairment as measured by the Skindex tool (t = −4.19, df = 43, P < 0.0001, mean difference = −18.87).16

In an interesting probe of the impact of HS on body image researchers in Germany using the Frankfurt Body Concept Scale found that HS significantly reduced body image (mean FKKS score, 234.2 [5.4] in patients and 276.9 [5.7] in controls; P < 0.001), even when controlled for BMI.17 A correlation was found for the extent of body image disruption and BMI (r = −0.589; P < 0.001), HADS-depression score (r = −0.619; P < 0.001), and HADS-anxiety score (r = −0.340; P = 0.03).

Population-Based Studies of HR-QoL in Hidradenitis Suppurativa

In a population-based study in Denmark, patients with HS had higher DLQI scores than controls and other patients with psoriasis, eczema or “pimples.18 In 55 patients attending community dermatology clinics in Canada. The mean DLQI score was 10 ± 8.8, indicating a moderate effect on patients” lives. The authors also assessed the Short Form – 36 version 2 questionnaire in these patients, SF-36v2 scores were significantly reduced with respect to both physical and mental health. The severity of disease, as measured by Hurley staging, the number of lesions, and patient-reported QoL were significantly correlated with the DLQI score (β = 0.549, 0.285, 0.390, respectively; p = 0.000, 0.045, 0.004, respectively; α = 0.05).19

Health -Related Quality of Life and Sexual Health and Sleep

Three hundred patients with HS showed diminished QoL and sexual health (Female Sexual Function Index: 21·6 ± 9·6, International Index of Erectile Function: 49·7 ± 20·7, Arizona Sexual Experience Scale: 16·7 ± 5·3, Dermatology Life Quality Index: 12·5 ± 7·5).20 Sexual health was associated with QoL in women but not in men. Female sex and late onset of HS were associated with poor sexual function. Impairment of QoL was associated with anogenital involvement, early onset of HS, disease severity and disease activity. In a study of 3845 dermatology patients in 13 countries, patients with HS had the highest rates of sexual impairment as measured using the DLQI.21 When compared with the male control group, male patients with HS had on average a lower sexual SQoLM (p < 0.0001) as measured by the Sexual Quality of Life Questionnaire for Use in Men (SQoLM) and International Index of Erectile Dysfunction (IIEF) (p < 0.019).21 Female patients had significantly higher distress related to sexual function as measured with the Female Sexual Distress Scale – Revised (FSDS-R). FSDS-R compared with healthy female volunteers (p = 0.002).

In recent work from Poland by Kaaz et al, patients with HS had poorer sleep quality than controls as measured by Pittsburgh Sleep Quality Index (PSQI). The mean scores for PSQI were 6.5±3.6 points (range 0–18) and 3.1 ±1.9 points (range 0–7) for patients with HS and control subjects, respectively (p<0.001).22 When considering insomnia as measured using the Athens Insomnia Scale there was no difference. Itch and pain were associated with poorer sleep quality.

Hidradenitis-Suppurativa Quality of Life: HS-QOL

The above studies and myriad of measures has led to an attempt at standardizing measures of Quality of Life in HS using a disease-specific measure the HS-QOL. This was developed to assimilate the three domains of skin-related QOL, impact on general well-being and psychosocial impairment and initially consisted of a 53-item questionnaire.23 The HS QOL was validated in 55 patients with HS in four different centres and showed good concordance.24 The HS-QoL was reduced from 53 items to 44 items, resulting in a 7-subscale questionnaire. All subscales demonstrated excellent internal consistency, except for the support subscale, which had adequate internal consistency. All 7 HS-QoL subscales were related to other measures of QoL, life satisfaction, and mental health, which demonstrates convergent validity.

Adalimumab and HRQoL in Hidradenitis Suppurativa

Adalimumab is the first licensed treatment for HS and the first indication that it impacted quality of life in patients with HS came from case-reports and small case series. In 6 Spanish patients treated with Adalimumab 40 mg fortnightly increasing to weekly, Bianco et al recorded significant reduction in DLQI 1 month and 1 year after commencing treatment.24 Amano et al also reported significant reduction in DLQI in 10 patients treated with Adalimumab 160 mg s/c week, 80 mg week 1 and 40 mg alternate weeks thereafter.25 In the next prospective study of adalimumab using the same dosage regimen, Miller et al reported a significant reduction in 21 patients with HS.26 In another prospective open-label study of the use of adalimumab 80 mg week 1 then 40 mg fortnightly for 24 weeks, 15 patients with moderate to severe HS experience significant drop in DLQI scores, scores began to rise again by week 48.27

There has been one Phase II parallel, randomized, placebo-controlled trial consisting of a blinded 16-week period (period 1) and an open-label 36-week period (period 2) of adalimumab administered in outpatient clinics in the US of adalimumab.28,29 Two Phase III trials, PIONEER I and II have also been conducted30-32 Kimball A and colleagues carried out a post-hoc analysis of the pooled data from Pioneer I and II studies to evaluate the impact of Hidradenitis Suppurativa Clinical Response (HiSCR) on PROM.33 Pooling placebo and active treatment arms, 39% of patients (245/629) achieved HiSCR at week 12. This included DLQI, Patients Global Assessment of Skin Pain Numeric Rating Scale (0–11), HS Quality of Life Numeric Rating Scale (0–11), The Work Productivity and Activity Impairment (WPAI) questionnaire, a validated instrument that evaluates 4 areas: work time missed because of HS (absenteeism), impairment while working because of HS (presenteeism), overall work impairment because of HS, and impairment of daily activities because of HS (activity impairment). The Treatment Satisfaction Questionnaire for Medication (TSQM) which includes assessments of the patient’s satisfaction with a medication’s effectiveness, lack of side effects, convenience, and global satisfaction with the medication. The TSQM is scaled from 0 to 100 points, with lower scores indicative of a greater dissatisfaction. Irrespective of treatment, significantly (p <0.05) more HiSCR responders than non-responders experienced clinically meaningful improvement in Dermatology Life Quality Index (60.5% vs 30.4%), Pain Numeric Rating Scale (46.9% vs 19.9%), hidradenitis suppurativa quality of life (49.4% vs 26.9%), work-related performance (52.6% vs 37.7%), and non-work-related performance (59.5% vs 33.3%).

Patient-reported outcomes and HR-Qol are probably more important in hidradenitis suppurativa than many other skin conditions. Although the use of multiple measures makes comparison across studies difficult there is consensus regarding the need for comprehensive measures of quality of life in HS and a move towards standardization. Adalimumab is the first treatment licensed for use in HS and has shown good results in DLQI, HsQol, pain, work-related and non-work-related performance.

It is evident that HS confers a considerable psychological burden on patients. The heterogeneity of patient reported outcomes applied to different inflammatory diseases precludes comparison with other skin diseases such as eczema and psoriasis. In a study from our clinic, we compared DLQI and HADS in patients with HS and patients with psoriasis (personal communication). Patients with HS had significantly higher scores in DLQI compared to patients with psoriasis (12.2 vs 9.9. p < 0.001). This was significant across all domains of the DLQI: daily activities, work, leisure activities, personal relationships and treatment. HS patients had significantly higher mean depression score on the HADS, 7.3 vs 4.2 in the psoriasis group, p< 0.001 and higher anxiety scores 9.6 vs 7.7 (p < 0.005). Assessment of psychological distress is embedded in treatment algorithms of psoriasis and this must be replicated in HS.