| Literature DB >> 32101371 |
Jixiang Zhu1,2,3, Xingwu Zhou1, Han-Jun Kim1, Moyuan Qu1,4, Xing Jiang1,5, KangJu Lee1, Li Ren1, Qingzhi Wu1, Canran Wang1, Xunmin Zhu2,3, Peyton Tebon1, Shiming Zhang1, Junmin Lee1, Nureddin Ashammakhi1,6,7, Samad Ahadian1, Mehmet Remzi Dokmeci1,6, Zhen Gu1,8,9, Wujin Sun1, Ali Khademhosseini1,6,8,9,7.
Abstract
The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.Entities:
Keywords: gelatin methacryloyl; microneedle patches; minimally invasive diagnostics; skin interstitial fluid; transdermal extraction
Year: 2020 PMID： 32101371 PMCID： PMC7182487 DOI： 10.1002/smll.201905910
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281