Literature DB >> 32101166

Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.

Gurmeet Kaur1, A Maxwell Burroughs1, Lakshminarayan M Iyer1, L Aravind1.   

Abstract

Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. We report the discovery of several thematically unified, remarkable biological conflict systems preponderantly present in multicellular prokaryotes. These combine thresholding mechanisms utilizing NTPase chaperones (the MoxR-vWA couple), GTPases and proteolytic cascades with hypervariable effectors, which vary either by using a reverse transcriptase-dependent diversity-generating system or through a system of acquisition of diverse protein modules, typically in inactive form, from various cellular subsystems. Conciliant lines of evidence indicate their deployment against invasive entities, like viruses, to limit their spread in multicellular/social contexts via physical containment, dominant-negative interactions or apoptosis. These findings argue for both a similar operational 'grammar' and shared protein domains in the sensing and limiting of infections during the multiple emergences of multicellularity.

Entities:  

Keywords:  AAA+ ATPase; DEATH domain; GTPase; apoptosis; chaperones; genetics; genomics; infectious disease; microbiology; multicellular prokaryotes

Mesh:

Substances:

Year:  2020        PMID: 32101166      PMCID: PMC7159879          DOI: 10.7554/eLife.52696

Source DB:  PubMed          Journal:  Elife        ISSN: 2050-084X            Impact factor:   8.140


  227 in total

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  8 in total

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