Literature DB >> 32097451

Commentary: Using human genetics to guide the repurposing of medicines.

Jonas Bovijn1,2, Jenny C Censin1,2, Cecilia M Lindgren1,2,3,4, Michael V Holmes1,3,5,6.   

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Year:  2020        PMID： 32097451      PMCID： PMC7660148          DOI： 10.1093/ije/dyaa015

Source DB:  PubMed          Journal:  Int J Epidemiol        ISSN： 0300-5771            Impact factor:   7.196


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  41 in total

1.  A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Authors:  Hai Fang; Hans De Wolf; Bogdan Knezevic; Katie L Burnham; Julie Osgood; Anna Sanniti; Alicia Lledó Lara; Silva Kasela; Stephane De Cesco; Jörg K Wegner; Lahiru Handunnetthi; Fiona E McCann; Liye Chen; Takuya Sekine; Paul E Brennan; Brian D Marsden; David Damerell; Chris A O'Callaghan; Chas Bountra; Paul Bowness; Yvonne Sundström; Lili Milani; Louise Berg; Hinrich W Göhlmann; Pieter J Peeters; Benjamin P Fairfax; Michael Sundström; Julian C Knight
Journal:  Nat Genet       Date:  2019-06-28       Impact factor: 38.330

2.  Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.

Authors:  Jack Bowden; George Davey Smith; Stephen Burgess
Journal:  Int J Epidemiol       Date:  2015-06-06       Impact factor: 7.196

3.  Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia.

Authors:  Yang Gao; Rónán O'Caoimh; Liam Healy; David M Kerins; Joseph Eustace; Gordon Guyatt; David Sammon; D William Molloy
Journal:  BMJ Open       Date:  2013-07-25       Impact factor: 2.692

4.  Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Authors:  Mary D Fortune; Hui Guo; Oliver Burren; Ellen Schofield; Neil M Walker; Maria Ban; Stephen J Sawcer; John Bowes; Jane Worthington; Anne Barton; Steve Eyre; John A Todd; Chris Wallace
Journal:  Nat Genet       Date:  2015-06-08       Impact factor: 38.330

5.  N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.

Authors:  Elena V Kugaevskaya; Alexander V Veselovsky; Maria I Indeykina; Nina I Solovyeva; Maria S Zharkova; Igor A Popov; Eugene N Nikolaev; Alexey B Mantsyzov; Alexander A Makarov; Sergey A Kozin
Journal:  Sci Rep       Date:  2018-01-10       Impact factor: 4.379

6.  Genomic atlas of the human plasma proteome.

Authors:  Benjamin B Sun; Joseph C Maranville; James E Peters; David Stacey; James R Staley; James Blackshaw; Stephen Burgess; Tao Jiang; Ellie Paige; Praveen Surendran; Clare Oliver-Williams; Mihir A Kamat; Bram P Prins; Sheri K Wilcox; Erik S Zimmerman; An Chi; Narinder Bansal; Sarah L Spain; Angela M Wood; Nicholas W Morrell; John R Bradley; Nebojsa Janjic; David J Roberts; Willem H Ouwehand; John A Todd; Nicole Soranzo; Karsten Suhre; Dirk S Paul; Caroline S Fox; Robert M Plenge; John Danesh; Heiko Runz; Adam S Butterworth
Journal:  Nature       Date:  2018-06-06       Impact factor: 49.962

7.  Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes.

Authors:  Brian A Ference; Jennifer G Robinson; Robert D Brook; Alberico L Catapano; M John Chapman; David R Neff; Szilard Voros; Robert P Giugliano; George Davey Smith; Sergio Fazio; Marc S Sabatine
Journal:  N Engl J Med       Date:  2016-12-01       Impact factor: 91.245

8.  Mendelian randomization of blood lipids for coronary heart disease.

Authors:  Michael V Holmes; Folkert W Asselbergs; Tom M Palmer; Fotios Drenos; Matthew B Lanktree; Christopher P Nelson; Caroline E Dale; Sandosh Padmanabhan; Chris Finan; Daniel I Swerdlow; Vinicius Tragante; Erik P A van Iperen; Suthesh Sivapalaratnam; Sonia Shah; Clara C Elbers; Tina Shah; Jorgen Engmann; Claudia Giambartolomei; Jon White; Delilah Zabaneh; Reecha Sofat; Stela McLachlan; Pieter A Doevendans; Anthony J Balmforth; Alistair S Hall; Kari E North; Berta Almoguera; Ron C Hoogeveen; Mary Cushman; Myriam Fornage; Sanjay R Patel; Susan Redline; David S Siscovick; Michael Y Tsai; Konrad J Karczewski; Marten H Hofker; W Monique Verschuren; Michiel L Bots; Yvonne T van der Schouw; Olle Melander; Anna F Dominiczak; Richard Morris; Yoav Ben-Shlomo; Jackie Price; Meena Kumari; Jens Baumert; Annette Peters; Barbara Thorand; Wolfgang Koenig; Tom R Gaunt; Steve E Humphries; Robert Clarke; Hugh Watkins; Martin Farrall; James G Wilson; Stephen S Rich; Paul I W de Bakker; Leslie A Lange; George Davey Smith; Alex P Reiner; Philippa J Talmud; Mika Kivimäki; Debbie A Lawlor; Frank Dudbridge; Nilesh J Samani; Brendan J Keating; Aroon D Hingorani; Juan P Casas
Journal:  Eur Heart J       Date:  2014-01-27       Impact factor: 29.983

9.  Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.

Authors:  Neil M Davies; Michael V Holmes; George Davey Smith
Journal:  BMJ       Date:  2018-07-12

10.  Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization.

Authors:  Kurt Taylor; George Davey Smith; Caroline L Relton; Tom R Gaunt; Tom G Richardson
Journal:  Genome Med       Date:  2019-01-31       Impact factor: 11.117
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  2 in total

Review 1.  Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.

Authors:  Michael V Holmes; Tom G Richardson; Brian A Ference; Neil M Davies; George Davey Smith
Journal:  Nat Rev Cardiol       Date:  2021-03-11       Impact factor: 32.419

2.  Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases.

Authors:  Oliver S Burren; Guillermo Reales; Limy Wong; John Bowes; James C Lee; Anne Barton; Paul A Lyons; Kenneth G C Smith; Wendy Thomson; Paul D W Kirk; Chris Wallace
Journal:  Genome Med       Date:  2020-11-25       Impact factor: 11.117
  2 in total

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