Esra Shishtar1,2, Gail T Rogers1, Jeffrey B Blumberg2, Rhoda Au3,4,5,6,7, Paul F Jacques1,2. 1. Nutritional Epidemiology Program, The Jean Mayer U.S.D.A. Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. 2. The Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. 3. The Framingham Heart Study, Boston University School of Medicine, Boston, MA, USA. 4. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. 5. Department of Neurology, Boston University School of Medicine, Boston, MA, USA. 6. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. 7. Boston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, USA.
Abstract
OBJECTIVE: To examine the association between long-term intake of total and the six classes of dietary flavonoids and decline in cognitive function over a follow-up period of up to 15 years. DESIGN: In this longitudinal study, we evaluated change in eight cognitive domain scores (verbal and visual memory, verbal learning, attention and concentration, abstract reasoning, language, visuoperceptual organisation and the global function) based on three neuropsychological exams and characterised the annualised change between consecutive exams. Long-term intakes of total and six flavonoid classes were assessed up to four times by a validated FFQ. Repeated-measures regression models were used to examine the longitudinal association between total and six flavonoid classes and annualised change in the eight cognitive domains. SETTING: The Framingham Heart Study (FHS), a prospective cohort study. PARTICIPANTS: One thousand seven hundred and seventy-nine subjects who were free of dementia, aged ≥45 years and had attended at least two of the last three FHS Offspring cohort study exams. RESULTS: Over a median follow-up of 11·8 years with 1779 participants, nominally significant trends towards a slower decline in cognitive function were observed among those with higher flavanol and flavon-3-ol intakes for global function, verbal and visual memory; higher total flavonoids and flavonoid polymers for visual memory; and higher flavanols for verbal learning. CONCLUSIONS: In spite of modest nominal trends, overall, our findings do not support a clear association between higher long-term flavonoid intake and slowing age-related cognitive decline.
OBJECTIVE: To examine the association between long-term intake of total and the six classes of dietary flavonoids and decline in cognitive function over a follow-up period of up to 15 years. DESIGN: In this longitudinal study, we evaluated change in eight cognitive domain scores (verbal and visual memory, verbal learning, attention and concentration, abstract reasoning, language, visuoperceptual organisation and the global function) based on three neuropsychological exams and characterised the annualised change between consecutive exams. Long-term intakes of total and six flavonoid classes were assessed up to four times by a validated FFQ. Repeated-measures regression models were used to examine the longitudinal association between total and six flavonoid classes and annualised change in the eight cognitive domains. SETTING: The Framingham Heart Study (FHS), a prospective cohort study. PARTICIPANTS: One thousand seven hundred and seventy-nine subjects who were free of dementia, aged ≥45 years and had attended at least two of the last three FHS Offspring cohort study exams. RESULTS: Over a median follow-up of 11·8 years with 1779 participants, nominally significant trends towards a slower decline in cognitive function were observed among those with higher flavanol and flavon-3-ol intakes for global function, verbal and visual memory; higher total flavonoids and flavonoid polymers for visual memory; and higher flavanols for verbal learning. CONCLUSIONS: In spite of modest nominal trends, overall, our findings do not support a clear association between higher long-term flavonoid intake and slowing age-related cognitive decline.
Authors: Lynda A Anderson; Richard A Goodman; Deborah Holtzman; Samuel F Posner; Mary E Northridge Journal: Am J Public Health Date: 2012-01-19 Impact factor: 9.308
Authors: Sarah J Nechuta; Bette J Caan; Wendy Y Chen; Wei Lu; Zhi Chen; Marilyn L Kwan; Shirley W Flatt; Ying Zheng; Wei Zheng; John P Pierce; Xiao Ou Shu Journal: Am J Clin Nutr Date: 2012-05-30 Impact factor: 7.045
Authors: Christy C Tangney; Hong Li; Yamin Wang; Lisa Barnes; Julie A Schneider; David A Bennett; Martha C Morris Journal: Neurology Date: 2014-09-17 Impact factor: 9.910
Authors: Aedín Cassidy; Éilis J O'Reilly; Colin Kay; Laura Sampson; Mary Franz; J P Forman; Gary Curhan; Eric B Rimm Journal: Am J Clin Nutr Date: 2010-11-24 Impact factor: 7.045
Authors: Mudi H Alharbi; Daniel J Lamport; Georgina F Dodd; Caroline Saunders; Laura Harkness; Laurie T Butler; Jeremy P E Spencer Journal: Eur J Nutr Date: 2015-08-18 Impact factor: 5.614
Authors: Emma Flanagan; Donnie Cameron; Rashed Sobhan; Chloe Wong; Matthew G Pontifex; Nicole Tosi; Pedro Mena; Daniele Del Rio; Saber Sami; Arjan Narbad; Michael Müller; Michael Hornberger; David Vauzour Journal: Front Nutr Date: 2022-05-19
Authors: Anna Zhu; Hui Chen; Jie Shen; Xiaoxi Wang; Zhihui Li; Ai Zhao; Xiaoming Shi; Lijing Yan; Yi Zeng; Changzheng Yuan; John S Ji Journal: Lancet Reg Health West Pac Date: 2022-01-05