Literature DB >> 3208754

Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding DNA.

H V Colot1, J C Hall, M Rosbash.   

Abstract

We have cloned and sequenced the coding region of the period (per) gene from Drosophila pseudoobscura and D. virilis. A comparison with that of D. melanogaster reveals that the conceptual translation products consist of interspersed blocks of conserved and non-conserved amino acid sequence. The non-conserved portion, comprising approximately 33% of the protein sequence, includes the perfect Thr-Gly repeat of D. melanogaster, which is absent from the D. pseudoobscura and D. virilis proteins. Based on these observations and cross-species transformation experiments, we suggest that the interspecific variability in the per primary amino acid sequence contributes to the control of species-specific behaviors.

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Year:  1988        PMID： 3208754      PMCID： PMC454982          DOI： 10.1002/j.1460-2075.1988.tb03279.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  44 in total

1.  opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.

Authors:  K A Wharton; B Yedvobnick; V G Finnerty; S Artavanis-Tsakonas
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

2.  Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster.

Authors:  Q Yu; A C Jacquier; Y Citri; M Hamblen; J C Hall; M Rosbash
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

3.  Improved tools for biological sequence comparison.

Authors:  W R Pearson; D J Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

4.  DNA fingerprinting in man using a mouse probe related to part of the Drosophila 'Per' gene.

Authors:  M Georges; P Cochaux; A S Lequarre; M W Young; G Vassart
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

5.  Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

Authors:  D R Cavener
Journal:  Nucleic Acids Res       Date:  1987-02-25       Impact factor: 16.971

6.  Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila.

Authors:  Q Yu; H V Colot; C P Kyriacou; J C Hall; M Rosbash
Journal:  Nature       Date:  1987 Apr 23-29       Impact factor: 49.962

7.  Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms.

Authors:  P Reddy; W A Zehring; D A Wheeler; V Pirrotta; C Hadfield; J C Hall; M Rosbash
Journal:  Cell       Date:  1984-10       Impact factor: 41.582

8.  Cryptic simplicity in DNA is a major source of genetic variation.

Authors:  D Tautz; M Trick; G A Dover
Journal:  Nature       Date:  1986 Aug 14-20       Impact factor: 49.962

9.  Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system.

Authors:  K K Siwicki; C Eastman; G Petersen; M Rosbash; J C Hall
Journal:  Neuron       Date:  1988-04       Impact factor: 17.173

10.  A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Authors:  R M Dale; B A McClure; J P Houchins
Journal:  Plasmid       Date:  1985-01       Impact factor: 3.466
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  51 in total

1.  Different period gene repeats take 'turns' at fine-tuning the circadian clock.

Authors:  V Guantieri; A Pepe; M Zordan; C P Kyriacou; R Costa; A M Tamburro
Journal:  Proc Biol Sci       Date:  1999-11-22       Impact factor: 5.349

2.  Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster.

Authors:  W M Michael; D D Bowtell; G M Rubin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

Review 3.  The molecular ethology of the period gene in Drosophila.

Authors:  C P Kyriacou
Journal:  Behav Genet       Date:  1990-03       Impact factor: 2.805

4.  Rates of synonymous substitution and base composition of nuclear genes in Drosophila.

Authors:  E N Moriyama; T Gojobori
Journal:  Genetics       Date:  1992-04       Impact factor: 4.562

5.  Cloning and analysis of the mobile element gypsy from D. virilis.

Authors:  L J Mizrokhi; A M Mazo
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

6.  Population genetics of the developmental gene optomotor-blind (omb) in Drosophila polymorpha: evidence for a role in abdominal pigmentation variation.

Authors:  Jennifer A Brisson; Alan R Templeton; Ian Duncan
Journal:  Genetics       Date:  2004-12       Impact factor: 4.562

7.  Two GC-rich DNA elements of Chlamydomonas reinhardtii with complex arrangements of directly repeated sequence motifs.

Authors:  W W Wakarchuk; F W Müller; C F Beck
Journal:  Plant Mol Biol       Date:  1992-01       Impact factor: 4.076

8.  The GTS1 gene, which contains a Gly-Thr repeat, affects the timing of budding and cell size of the yeast Saccharomyces cerevisiae.

Authors:  K Mitsui; S Yaguchi; K Tsurugi
Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

9.  A combined molecular and cytogenetic approach to genome evolution in Drosophila using large-fragment DNA cloning.

Authors:  E R Lozovskaya; D A Petrov; D L Hartl
Journal:  Chromosoma       Date:  1993-03       Impact factor: 4.316

10.  A new type of putative non-visual photoreceptors in the optic lobe of beetles.

Authors:  G Fleissner; G Fleissner; B Frisch
Journal:  Cell Tissue Res       Date:  1993-09       Impact factor: 5.249
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