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Literature DB >> 32081027

Dynamic N6-methyladenosine RNA methylation in brain and diseases.

Andrew M Shafik¹, Emily G Allen¹, Peng Jin¹.

Abstract

N6-methyladenosine (m6A) is a dynamic RNA modification that regulates various aspects of RNA metabolism and has been implicated in many biological processes and transitions. m6A is highly abundant in the brain; however, only recently has the role of m6A in brain development been a focus. The machinery that controls m6A is critically important for proper neurodevelopment, and the precise mechanisms by which m6A regulates these processes are starting to emerge. However, the role of m6A in neurodegenerative and neuropsychiatric diseases still requires much elucidation. This review discusses and summarizes the current body of knowledge surrounding the function of the m6A modification in regulating normal brain development, neurodegenerative diseases and outlines possible future directions.

Entities: Chemical Disease Gene

Keywords: N6-methyladenosine; epitranscriptomics; neurodegenerative disease; neurodevelopment; neurogenesis

Mesh：

Substances：

Year: 2020 PMID： 32081027 PMCID： PMC7132785 DOI： 10.2217/epi-2019-0260

Source DB: PubMed Journal: Epigenomics ISSN： 1750-192X Impact factor: 4.778

62 in total

1. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

Authors: B A Reynolds; S Weiss
Journal: Science Date: 1992-03-27 Impact factor: 47.728

2. Cytoplasmic m⁶A reader YTHDF3 promotes mRNA translation.

Authors: Ang Li; Yu-Sheng Chen; Xiao-Li Ping; Xin Yang; Wen Xiao; Ying Yang; Hui-Ying Sun; Qin Zhu; Poonam Baidya; Xing Wang; Devi Prasad Bhattarai; Yong-Liang Zhao; Bao-Fa Sun; Yun-Gui Yang
Journal: Cell Res Date: 2017-01-20 Impact factor: 25.617

Review 3. Genomic perspectives of transcriptional regulation in forebrain development.

Authors: Alex S Nord; Kartik Pattabiraman; Axel Visel; John L R Rubenstein
Journal: Neuron Date: 2015-01-07 Impact factor: 17.173

4. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

Authors: Lifang Mu; Lucia Berti; Giacomo Masserdotti; Marcela Covic; Theologos M Michaelidis; Kathrin Doberauer; Katharina Merz; Frederick Rehfeld; Anja Haslinger; Michael Wegner; Elisabeth Sock; Veronique Lefebvre; Sebastien Couillard-Despres; Ludwig Aigner; Benedikt Berninger; D Chichung Lie
Journal: J Neurosci Date: 2012-02-29 Impact factor: 6.167

Review 5. Post-transcriptional gene regulation by mRNA modifications.

Authors: Boxuan Simen Zhao; Ian A Roundtree; Chuan He
Journal: Nat Rev Mol Cell Biol Date: 2016-11-03 Impact factor: 94.444

6. N⁶-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Authors: Yang Wang; Yue Li; Minghui Yue; Jun Wang; Sandeep Kumar; Robert J Wechsler-Reya; Zhaolei Zhang; Yuya Ogawa; Manolis Kellis; Gregg Duester; Jing Crystal Zhao
Journal: Nat Neurosci Date: 2018-01-15 Impact factor: 24.884

7. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Authors: Guanqun Zheng; John Arne Dahl; Yamei Niu; Peter Fedorcsak; Chun-Min Huang; Charles J Li; Cathrine B Vågbø; Yue Shi; Wen-Ling Wang; Shu-Hui Song; Zhike Lu; Ralph P G Bosmans; Qing Dai; Ya-Juan Hao; Xin Yang; Wen-Ming Zhao; Wei-Min Tong; Xiu-Jie Wang; Florian Bogdan; Kari Furu; Ye Fu; Guifang Jia; Xu Zhao; Jun Liu; Hans E Krokan; Arne Klungland; Yun-Gui Yang; Chuan He
Journal: Mol Cell Date: 2012-11-21 Impact factor: 17.970

8. Region-specific RNA m⁶A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

Authors: Mengqi Chang; Hongyi Lv; Weilong Zhang; Chunhui Ma; Xue He; Shunli Zhao; Zhi-Wei Zhang; Yi-Xin Zeng; Shuhui Song; Yamei Niu; Wei-Min Tong
Journal: Open Biol Date: 2017-09 Impact factor: 6.411

9. RNA m⁶A methylation participates in regulation of postnatal development of the mouse cerebellum.

Authors: Chunhui Ma; Mengqi Chang; Hongyi Lv; Zhi-Wei Zhang; Weilong Zhang; Xue He; Gaolang Wu; Shunli Zhao; Yao Zhang; Di Wang; Xufei Teng; Chunying Liu; Qing Li; Arne Klungland; Yamei Niu; Shuhui Song; Wei-Min Tong
Journal: Genome Biol Date: 2018-05-31 Impact factor: 13.583

Dynamic N6-methyladenosine RNA methylation in brain and diseases.

1. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

2. Cytoplasmic m⁶A reader YTHDF3 promotes mRNA translation.

Review 3. Genomic perspectives of transcriptional regulation in forebrain development.

4. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

Review 5. Post-transcriptional gene regulation by mRNA modifications.

6. N⁶-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

7. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

8. Region-specific RNA m⁶A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

9. RNA m⁶A methylation participates in regulation of postnatal development of the mouse cerebellum.

10. Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.

Review 1. Epitranscriptomic dynamics in brain development and disease.

Review 2. An epigenetic 'extreme makeover': the methylation of flaviviral RNA (and beyond).

3. Alteration of N ⁶ -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia-Reperfusion Injury.

Review 4. Recent Major Transcriptomics and Epitranscriptomics Contributions toward Personalized and Precision Medicine.

5. METTL3-mediated maturation of miR-589-5p promotes the malignant development of liver cancer.

6. Prognostic value of m6A regulators and the nomogram construction in glioma patients.