Literature DB >> 3207426

Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA.

S Pol1, B Bousquet-Lemercier, M Pave-Preux, A Pawlak, B Nalpas, P Berthelot, J Hanoune, R Barouki.   

Abstract

The cDNA of human mitochondrial aspartate aminotransferase (E.C.2.6.1.1.) was isolated from a human liver cDNA library using a rat mitochondrial aspartate aminotransferase cDNA as probe. The sequence of this cDNA gives a predicted aminoacid sequence for the human presequence and for the human mature protein exhibiting respectively 93% and 95% homology with rat sequences. A Northern blot of total RNA, isolated from various human tissues and hybridized with this cDNA, revealed a single 2.4 Kb RNA band. Mitochondrial aspartate aminotransferase RNA was clearly detected in human kidney, placenta, stomach and spleen as well as in both fetal and adult liver.

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Year:  1988        PMID： 3207426     DOI： 10.1016/s0006-291x(88)81017-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Molecular cloning of a cDNA encoding aspartate aminotransferase-P2 from lupin root nodules.

Authors:  P H Reynolds; L A Smith; J M Dickson; W T Jones; S D Jones; K A Rodber; A Carne; C P Liddane
Journal:  Plant Mol Biol       Date:  1992-06       Impact factor: 4.076

2.  Genomic structure, expression and evolution of the alfalfa aspartate aminotransferase genes.

Authors:  R G Gregerson; S S Miller; M Petrowski; J S Gantt; C P Vance
Journal:  Plant Mol Biol       Date:  1994-06       Impact factor: 4.076

3.  The amino acid sequence of cytosolic aspartate aminotransferase from human liver.

Authors:  J M Doyle; M E Schininà; F Bossa; S Doonan
Journal:  Biochem J       Date:  1990-09-15       Impact factor: 3.857

4.  Rapid purification and thermostability of the cytoplasmic aspartate aminotransferase from carrot suspension cultures.

Authors:  F J Turano; B J Wilson; B F Matthews
Journal:  Plant Physiol       Date:  1991-10       Impact factor: 8.340

5.  Isolation and analysis of a cDNA clone that encodes an alfalfa (Medicago sativa) aspartate aminotransferase.

Authors:  M K Udvardi; M L Kahn
Journal:  Mol Gen Genet       Date:  1991-12

6.  Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.

Authors:  S Pol; B Bousquet-Lemercier; M Pavé-Preux; F Bulle; E Passage; J Hanoune; M G Mattei; R Barouki
Journal:  Hum Genet       Date:  1989-09       Impact factor: 4.132

7.  Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.

Authors:  James H Lewis; Michel Jadoul; Geoffrey A Block; Melanie P Chin; Deborah A Ferguson; Angie Goldsberry; Colin J Meyer; Megan O'Grady; Pablo E Pergola; Scott A Reisman; W Christian Wigley; Glenn M Chertow
Journal:  Clin Transl Sci       Date:  2020-09-03       Impact factor: 4.689
  7 in total

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