Luc P Brion1, Charles R Rosenfeld2, Roy Heyne2, L Steven Brown3, Cheryl S Lair3, Elen Petrosyan3, Theresa Jacob3, Maria Caraig2, Patti J Burchfield2. 1. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX, USA. luc.brion@utsouthwestern.edu. 2. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX, USA. 3. Parkland Health & Hospital System, Dallas, TX, USA.
Abstract
OBJECTIVE: In preterm neonates fed human milk, fortification may be adjusted by (1) optimization, based on growth rate and serum nutrient analyses, or (2) individualization, based on serial milk nutrient analyses. The primary aim was to determine whether individualized plus optimized nutrition (experimental) improves velocity of weight gain and linear growth from birth to endpoint (36 weeks postmenstrual age or discharge) when compared with optimized nutrition alone (controls). STUDY DESIGN: Double-blinded parallel group randomized trial in 120 neonates <29 weeks gestational age (GA) or <35 weeks and small for GA (birth weight < 10th centile). RESULT: Weight-gain velocity (13.1 ± 2.1, n = 57 controls, vs. 13.0 ± 2.6 g kg-1 day-1, n = 59 experimental, P = 0.87), linear growth (0.9 ± 0.2, n = 55, vs. 0.9 ± 0.2 cm week-1, n = 52, P = 0.90) and frequency of weight/length disproportion (2% vs. 2%, P = 0.98) were similar in both groups. CONCLUSIONS: Individualized plus optimized nutrition does not improve weight gain, linear growth, or weight/length disproportion at endpoint versus optimized nutrition alone.
RCT Entities:
OBJECTIVE: In preterm neonates fed human milk, fortification may be adjusted by (1) optimization, based on growth rate and serum nutrient analyses, or (2) individualization, based on serial milk nutrient analyses. The primary aim was to determine whether individualized plus optimized nutrition (experimental) improves velocity of weight gain and linear growth from birth to endpoint (36 weeks postmenstrual age or discharge) when compared with optimized nutrition alone (controls). STUDY DESIGN: Double-blinded parallel group randomized trial in 120 neonates <29 weeks gestational age (GA) or <35 weeks and small for GA (birth weight < 10th centile). RESULT: Weight-gain velocity (13.1 ± 2.1, n = 57 controls, vs. 13.0 ± 2.6 g kg-1 day-1, n = 59 experimental, P = 0.87), linear growth (0.9 ± 0.2, n = 55, vs. 0.9 ± 0.2 cm week-1, n = 52, P = 0.90) and frequency of weight/length disproportion (2% vs. 2%, P = 0.98) were similar in both groups. CONCLUSIONS: Individualized plus optimized nutrition does not improve weight gain, linear growth, or weight/length disproportion at endpoint versus optimized nutrition alone.
Authors: Lara Pavageau; Charles R Rosenfeld; Roy Heyne; L Steven Brown; Jenna Whitham; Cheryl Lair; Luc P Brion Journal: J Perinatol Date: 2018-09-28 Impact factor: 2.521
Authors: C Agostoni; G Buonocore; V P Carnielli; M De Curtis; D Darmaun; T Decsi; M Domellöf; N D Embleton; C Fusch; O Genzel-Boroviczeny; O Goulet; S C Kalhan; S Kolacek; B Koletzko; A Lapillonne; W Mihatsch; L Moreno; J Neu; B Poindexter; J Puntis; G Putet; J Rigo; A Riskin; B Salle; P Sauer; R Shamir; H Szajewska; P Thureen; D Turck; J B van Goudoever; E E Ziegler Journal: J Pediatr Gastroenterol Nutr Date: 2010-01 Impact factor: 2.839
Authors: Luc P Brion; Charles R Rosenfeld; Roy Heyne; Steven L Brown; Cheryl S Lair; Patti J Burchfield; Maria Caraig Journal: J Perinatol Date: 2019-07-01 Impact factor: 2.521
Authors: Luc P Brion; Roy Heyne; L Steven Brown; Cheryl S Lair; Audrey Edwards; Patti J Burchfield; Maria Caraig Journal: J Perinatol Date: 2020-08-12 Impact factor: 2.521
Authors: Jessica Wickland; L Steven Brown; Valerie Blanco; Roy Heyne; Christy Turer; Charles R Rosenfeld Journal: Pediatr Res Date: 2022-04-28 Impact factor: 3.756
Authors: Veronica Fabrizio; Jennifer M Trzaski; Elizabeth A Brownell; Patricia Esposito; Shabnam Lainwala; Mary M Lussier; James I Hagadorn Journal: Cochrane Database Syst Rev Date: 2020-11-23