Luc P Brion1, Roy Heyne2, L Steven Brown3, Cheryl S Lair3, Audrey Edwards3, Patti J Burchfield2, Maria Caraig2. 1. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. luc.brion@utsouthwestern.edu. 2. Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3. Parkland Health and Hospital System, Dallas, TX, USA.
Abstract
OBJECTIVE: To assess the relationship of size for age with zinc deficiency in extremely low gestational age (GA) infants (23-28 weeks, ELGANs) who had insufficient linear growth despite optimizing other nutrients and to analyze changes in fronto-occipital circumference (FOC), weight and length with zinc supplementation. STUDY DESIGN: Retrospective cohort study. RESULTS: Among 302 ELGANs, a serum zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc deficiency (serum concentration <0.74 mcg/ml) was diagnosed in 8 of 24 (33%) small for GA (SGA) compared to 35 of 278 (13%) non-SGA infants (P = 0.01). Zinc supplementation for >2 weeks improved FOC growth to discharge or 50 weeks postmenstrual age in infants with Zn deficiency. However, neither linear growth nor weight gain improved with Zn supplementation. CONCLUSION: Zinc deficiency was diagnosed in 14% ELGANs in this cohort. Zinc supplementation for >2 weeks improved FOC growth but not linear growth or weight gain.
OBJECTIVE: To assess the relationship of size for age with zinc deficiency in extremely low gestational age (GA) infants (23-28 weeks, ELGANs) who had insufficient linear growth despite optimizing other nutrients and to analyze changes in fronto-occipital circumference (FOC), weight and length with zinc supplementation. STUDY DESIGN: Retrospective cohort study. RESULTS: Among 302 ELGANs, a serum zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc deficiency (serum concentration <0.74 mcg/ml) was diagnosed in 8 of 24 (33%) small for GA (SGA) compared to 35 of 278 (13%) non-SGA infants (P = 0.01). Zinc supplementation for >2 weeks improved FOC growth to discharge or 50 weeks postmenstrual age in infants with Zn deficiency. However, neither linear growth nor weight gain improved with Zn supplementation. CONCLUSION:Zinc deficiency was diagnosed in 14% ELGANs in this cohort. Zinc supplementation for >2 weeks improved FOC growth but not linear growth or weight gain.
Authors: Lara Pavageau; Charles R Rosenfeld; Roy Heyne; L Steven Brown; Jenna Whitham; Cheryl Lair; Luc P Brion Journal: J Perinatol Date: 2018-09-28 Impact factor: 2.521
Authors: Axel R Franz; Frank Pohlandt; Harald Bode; Walter A Mihatsch; Silvia Sander; Martina Kron; Jochen Steinmacher Journal: Pediatrics Date: 2009-01 Impact factor: 7.124
Authors: Gianluca Terrin; Roberto Berni Canani; Maria Di Chiara; Andrea Pietravalle; Vincenzo Aleandri; Francesca Conte; Mario De Curtis Journal: Nutrients Date: 2015-12-11 Impact factor: 5.717
Authors: Jordan D Reis; Kristine Tolentino-Plata; Roy Heyne; L Steven Brown; Charles R Rosenfeld; Maria Caraig; Patti J Burchfield; Luc P Brion Journal: J Perinatol Date: 2021-03-26 Impact factor: 3.225