Literature DB >> 32068230

Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure.

Ana R Araújo1, Sergio Camero2, Pablo Taboada3, Rui L Reis1, Ricardo A Pires1.   

Abstract

The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.

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Year:  2020        PMID： 32068230     DOI： 10.1039/d0cc00192a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Glucosamine and Its Analogues as Modulators of Amyloid-β Toxicity.

Authors:  Ana R Araújo; Vânia I B Castro; Rui L Reis; Ricardo A Pires
Journal:  ACS Med Chem Lett       Date:  2021-03-24       Impact factor: 4.345

Review 2.  Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors:  Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal:  Chem Rev       Date:  2021-02-05       Impact factor: 60.622

3.  Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms.

Authors:  Ana R Araújo; Juan Correa; Vicente Dominguez-Arca; Rui L Reis; Eduardo Fernandez-Megia; Ricardo A Pires
Journal:  ACS Appl Mater Interfaces       Date:  2021-12-07       Impact factor: 9.229
  3 in total

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