| Literature DB >> 32061776 |
Paul D Kruithof1, Sergey Lunev1, Sheila P Aguilar Lozano1, Fernando de Assis Batista1, Zayana M Al-Dahmani1, Jaap A Joles2, Amalia M Dolga3, Matthew R Groves1, Harry van Goor4.
Abstract
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.Entities:
Keywords: Antioxidant systems; Diabetes; Obesity; Rhodanese; Sulfurtransferase; TST
Year: 2020 PMID： 32061776 DOI： 10.1016/j.bbadis.2020.165716
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187