Jiao Qi1, Wenwen He1, Qiang Lu1, Keke Zhang1, Yi Lu1, Xiangjia Zhu2. 1. Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People's Republic of China; Key Laboratory of Myopia, Ministry of Health, People's Republic of China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China; Shanghai High Myopia Study Group, Shanghai, People's Republic of China; Visual Rehabilitation Professional Committee, Chinese Association of Rehabilitation Medicine, People's Republic of China. 2. Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People's Republic of China; Key Laboratory of Myopia, Ministry of Health, People's Republic of China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China; Shanghai High Myopia Study Group, Shanghai, People's Republic of China; Visual Rehabilitation Professional Committee, Chinese Association of Rehabilitation Medicine, People's Republic of China. Electronic address: zhuxiangjia1982@126.com.
Abstract
PURPOSE: To investigate the morphological features of Schlemm's canal and trabecular meshwork in highly myopic eyes with early intraocular pressure (IOP) elevation after cataract surgery. DESIGN: Retrospective case-control study METHODS: Eighty-eight highly myopic eyes of 88 patients after uneventful cataract surgery were included, 31 of which had early postoperative IOP elevation and 57 of which did not. The morphological features of Schlemm's canal and trabecular meshwork, collected with swept-source optical coherence tomography before surgery, were reviewed. Backwards stepwise multiple linear regression was used to investigate the anatomical risk factors for early IOP elevation in highly myopic eyes. RESULTS: Highly myopic eyes with early postoperative IOP elevation had smaller Schlemm's canal vertical diameter and area, as well as smaller trabecular meshwork thickness and width, in each quadrant than the non-elevation group. There was no significant difference in Schlemm's canal horizontal diameter between the IOP elevation and non-elevation groups. In the highly myopic eyes, average Schlemm's canal vertical diameter, Schlemm's canal area, trabecular meshwork thickness and width were all correlated negatively with the IOP elevation. A multivariate analysis showed that average Schlemm's canal vertical diameter (β = -0.262, p = 0.004) and trabecular meshwork thickness (β = -0.173, p < 0.001) were significantly associated with early transient IOP elevation in highly myopic cataract eyes. CONCLUSIONS: A smaller vertical diameter of Schlemm's canal and a thinner trabecular meshwork are two anatomical risk factors for early IOP elevation after cataract surgery in highly myopic eyes.
PURPOSE: To investigate the morphological features of Schlemm's canal and trabecular meshwork in highly myopic eyes with early intraocular pressure (IOP) elevation after cataract surgery. DESIGN: Retrospective case-control study METHODS: Eighty-eight highly myopic eyes of 88 patients after uneventful cataract surgery were included, 31 of which had early postoperative IOP elevation and 57 of which did not. The morphological features of Schlemm's canal and trabecular meshwork, collected with swept-source optical coherence tomography before surgery, were reviewed. Backwards stepwise multiple linear regression was used to investigate the anatomical risk factors for early IOP elevation in highly myopic eyes. RESULTS: Highly myopic eyes with early postoperative IOP elevation had smaller Schlemm's canal vertical diameter and area, as well as smaller trabecular meshwork thickness and width, in each quadrant than the non-elevation group. There was no significant difference in Schlemm's canal horizontal diameter between the IOP elevation and non-elevation groups. In the highly myopic eyes, average Schlemm's canal vertical diameter, Schlemm's canal area, trabecular meshwork thickness and width were all correlated negatively with the IOP elevation. A multivariate analysis showed that average Schlemm's canal vertical diameter (β = -0.262, p = 0.004) and trabecular meshwork thickness (β = -0.173, p < 0.001) were significantly associated with early transient IOP elevation in highly myopic cataract eyes. CONCLUSIONS: A smaller vertical diameter of Schlemm's canal and a thinner trabecular meshwork are two anatomical risk factors for early IOP elevation after cataract surgery in highly myopic eyes.