Literature DB >> 32060847

CCL21 Programs Immune Activity in Tumor Microenvironment.

Sherven Sharma1,2,3, Pournima Kadam4, Steven Dubinett5,4,6.   

Abstract

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated immune activity in the TME. Immune escape mechanisms are upregulated in the TME that promote tumor immune evasion. CCL21 combined with inhibition of dominant pathways of immune evasion will aid in the development of effective immunotherapy for cancer.

Entities:  

Keywords:  Activated T cells; Antigen-presenting cells; CCL21; Dendritic cells; Immune activity; Immune checkpoint blockade; Immune suppression; Immunotherapy; Programmed cell death protein 1 (PD-1); T cells; Tumor microenvironment

Mesh：

Substances：

Year:  2020        PMID： 32060847     DOI： 10.1007/978-3-030-36667-4_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  9 in total

1.  Metabolic reprogramming of macrophages instigates CCL21-induced arthritis.

Authors:  Katrien Van Raemdonck; Sadiq Umar; Karol Palasiewicz; Anja Meyer; Michael V Volin; Huan J Chang; Mina Al-Awqati; Ryan K Zomorrodi; Shiva Shahrara
Journal:  Immunol Cell Biol       Date:  2021-12-06       Impact factor: 5.126

Review 2.  Role of chemokine systems in cancer and inflammatory diseases.

Authors:  Hongyi Li; Min Wu; Xia Zhao
Journal:  MedComm (2020)       Date:  2022-06-08

3.  Development and Validation of a Novel Immune-Gene Pairs Prognostic Model Associated with CTNNB1 Alteration in Hepatocellular Carcinoma.

Authors:  Junyu Huo; Liqun Wu; Yunjin Zang
Journal:  Med Sci Monit       Date:  2020-09-18

4.  Technical Feasibility and Safety of Repeated Computed Tomography-Guided Transthoracic Intratumoral Injection of Gene-Modified Cellular Immunotherapy in Metastatic NSCLC.

Authors:  Puja Shahrouki; Jay M Lee; Jonathan Barclay; Sarah N Khan; Scott Genshaft; Fereidoun Abtin; Steven M Dubinett; Aaron Lisberg; Sherven Sharma; Edward B Garon; Robert Suh
Journal:  JTO Clin Res Rep       Date:  2021-10-14

5.  Bioinformatics Analysis Revealing the Correlation between NF-κB Signaling Pathway and Immune Infiltration in Gastric Cancer.

Authors:  Qiuxiang Chen; Xiaojing Du; Pengcheng Ruan; Yumei Ye; Jin Zheng; Sunkuan Hu
Journal:  Comput Math Methods Med       Date:  2022-07-28       Impact factor: 2.809

6.  A Study of Heat Shock Protein 90 and Serum CCL21 Expression in Pregnant Women with Preeclampsia.

Authors:  Weina Yang; Xuemei Yang; Su'e Zhang; Limei Zhang; Wenze Wang; Li Wang
Journal:  Evid Based Complement Alternat Med       Date:  2022-08-02       Impact factor: 2.650

7.  Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer.

Authors:  Janna Berg; Ann Rita Halvorsen; May-Bente Bengtson; Morten Lindberg; Bente Halvorsen; Pål Aukrust; Åslaug Helland; Thor Ueland
Journal:  Front Immunol       Date:  2022-07-14       Impact factor: 8.786

Review 8.  STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development.

Authors:  Jessica N Filderman; Mark Appleman; Manoj Chelvanambi; Jennifer L Taylor; Walter J Storkus
Journal:  Front Immunol       Date:  2021-05-13       Impact factor: 7.561

9.  Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm.

Authors:  Xiaoqing Shen; Zhujuan Yang; Songwei Feng; Yi Li
Journal:  World J Surg Oncol       Date:  2021-07-28       Impact factor: 2.754
  9 in total

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