Contrast Normalization Accounts for Binocular Interactions in Human Striate and Extra-striate Visual Cortex.

During binocular viewing, visual inputs from the two eyes interact at the level of visual cortex. Here we studied binocular interactions in human visual cortex, including both sexes, using source-imaged steady-state visual evoked potentials over a wide range of relative contrast between two eyes. The ROIs included areas V1, V3a, hV4, hMT+, and lateral occipital cortex. Dichoptic parallel grating stimuli in each eye modulated at distinct temporal frequencies allowed us to quantify spectral components associated with the individual stimuli from monocular inputs (self-terms) and responses due to interaction between the inputs from the two eyes (intermodulation [IM] terms). Data with self-terms revealed an interocular suppression effect, in which the responses to the stimulus in one eye were reduced when a stimulus was presented simultaneously to the other eye. The suppression magnitude varied depending on visual area, and the relative contrast between the two eyes. Suppression was strongest in V1 and V3a (50% reduction) and was least in lateral occipital cortex (20% reduction). Data with IM terms revealed another form of binocular interaction, compared with self-terms. IM response was strongest at V1 and was least in hV4. Fits of a family of divisive gain control models to both self- and IM-term responses within each cortical area indicated that both forms of binocular interaction shared a common gain control nonlinearity. However, our model fits revealed different patterns of binocular interaction along the cortical hierarchy, particularly in terms of excitatory and suppressive contributions.SIGNIFICANCE STATEMENT Using source-imaged steady-state visual evoked potentials and frequency-domain analysis of dichoptic stimuli, we measured two forms of binocular interactions: one is associated with the individual stimuli that represent interocular suppression from each eye, and the other is a direct measure of interocular interaction between inputs from the two eyes. We demonstrated that both forms of binocular interactions share a common gain control mechanism in striate and extra-striate cortex. Furthermore, our model fits revealed different patterns of binocular interaction along the visual cortical hierarchy, particularly in terms of excitatory and suppressive contributions.