| Literature DB >> 32059776 |
Yongchao Dou1, Emily A Kawaler2, Daniel Cui Zhou3, Marina A Gritsenko4, Chen Huang1, Lili Blumenberg5, Alla Karpova3, Vladislav A Petyuk4, Sara R Savage1, Shankha Satpathy6, Wenke Liu2, Yige Wu3, Chia-Feng Tsai4, Bo Wen1, Zhi Li2, Song Cao3, Jamie Moon4, Zhiao Shi1, MacIntosh Cornwell2, Matthew A Wyczalkowski3, Rosalie K Chu4, Suhas Vasaikar7, Hua Zhou2, Qingsong Gao3, Ronald J Moore4, Kai Li1, Sunantha Sethuraman3, Matthew E Monroe4, Rui Zhao4, David Heiman6, Karsten Krug6, Karl Clauser6, Ramani Kothadia6, Yosef Maruvka6, Alexander R Pico8, Amanda E Oliphant9, Emily L Hoskins9, Samuel L Pugh9, Sean J I Beecroft9, David W Adams9, Jonathan C Jarman9, Andy Kong10, Hui-Yin Chang10, Boris Reva11, Yuxing Liao1, Dmitry Rykunov11, Antonio Colaprico12, Xi Steven Chen12, Andrzej Czekański13, Marcin Jędryka13, Rafał Matkowski13, Maciej Wiznerowicz14, Tara Hiltke15, Emily Boja15, Christopher R Kinsinger15, Mehdi Mesri15, Ana I Robles15, Henry Rodriguez15, David Mutch16, Katherine Fuh16, Matthew J Ellis1, Deborah DeLair17, Mathangi Thiagarajan18, D R Mani6, Gad Getz6, Michael Noble6, Alexey I Nesvizhskii19, Pei Wang11, Matthew L Anderson20, Douglas A Levine21, Richard D Smith4, Samuel H Payne9, Kelly V Ruggles5, Karin D Rodland22, Li Ding23, Bing Zhang24, Tao Liu25, David Fenyö26.
Abstract
We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.Entities:
Keywords: CTNNB1; TP53; acetylation; circular RNA; endometrial cancer; endometrioid endometrial cancer; immune evasion; proteogenomics; proteomics; serous endometrial cancer
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Year: 2020 PMID： 32059776 PMCID： PMC7233456 DOI： 10.1016/j.cell.2020.01.026
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582