Literature DB >> 32056542

Altered level of salivary placental growth factor is associated with preeclampsia.

Shannon L Rao1, Ada Taymoori2, David T W Wong1, Jill L Maron3.   

Abstract

A pilot, case-control study was conducted to compare the concentrations of placental growth factor (PlGF) and placental alkaline phosphatase (PLAP) in saliva of preeclampsia (PE) patients with normotensive controls in the second and third trimesters. Measured by ELISA assays, levels of salivary PlGF were significantly lower in PE patients (n = 13) compared to controls (n = 15) (two-way ANOVA, p = 0.0208) independent of gestational age at time of collection (p = 0.49). Salivary PLAP differences between PE and controls were not statistically significant. Placenta-specific proteins are detectable in maternal saliva and may serve as noninvasive biomarkers to monitor placenta health and disease during pregnancy.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Angiogenic factor; Preeclampsia; Salivary biomarker

Mesh：

Substances：

Year:  2019        PMID： 32056542      PMCID： PMC7024063          DOI： 10.1016/j.placenta.2019.12.016

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  20 in total

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9.  Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio: A Prospective Cohort Study of Unselected Nulliparous Women.

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