Robert G Martindale1, David Berlana2, Joseph I Boullata3,4, Wei Cai5, Philip C Calder6,7, Girish H Deshpande8,9, David Evans10, Abelardo Garcia-de-Lorenzo11, Olivier J Goulet12, Ang Li13, Konstantin Mayer14, Manpreet S Mundi15, Maurizio Muscaritoli16, Lorenzo Pradelli17, Martin Rosenthal18, Jeong-Meen Seo19, Dan L Waitzberg20, Stanislaw Klek21. 1. Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA. 2. Pharmacy Service, Vall d'Hebron Barcelona Hospital Campus and Department of Nutrition, University of Barcelona, Barcelona, Spain. 3. Department of Nutrition Sciences, Drexel University, Philadelphia, Pennsylvania, USA. 4. Clinical Nutrition Support Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. 5. Department of Pediatric Surgery, Division of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 6. Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. 7. NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. 8. Neonatal NICU, Nepean Hospital, Kingswood, NSW, Australia. 9. Sydney Medical School, Nepean, University of Sydney, Australia. 10. Department of Surgery, Ohio State University Medical Center, Columbus, Ohio, USA. 11. Intensive Care Medicine Department, La Paz University Hospital, Madrid, Spain. 12. Department of Pediatric Gastroenterology, Hepatology and Nutrition, Intestinal Failure Rehabilitation Center, National Reference Center for Rare Digestive Diseases, Hospital Necker-Enfants Malades, University of Paris-Descartes, Paris, France. 13. Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China. 14. Vidia Kliniken Karlsruhe, Medizinische Klinik IV, Karlsruhe, Germany. 15. Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA. 16. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy. 17. AdRes Health Economics and Outcomes Research, Turin, Italy. 18. Department of Surgery, Division of Trauma and Acute Surgery, University of Florida College of Medicine, Gainesville, Florida, USA. 19. Division of Pediatric Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. 20. Department of Gastroenterology, Lim 35, School of Medicine, University of São Paulo, São Paulo, Brazil. 21. Department of General and Oncology Surgery, Intestinal Failure Unit, Stanley Dudrick's Memorial Hospital, Skawina, Poland.
Abstract
BACKGROUND: The 2018 Lipids in Parenteral Nutrition summit involved a panel of experts in clinical nutrition, lipid metabolism, and pharmacology, to assess the current state of knowledge and develop expert consensus statements regarding the use of intravenous lipid emulsions in various patient populations and clinical settings. The main purpose of the consensus statements is to assist healthcare professionals by providing practical guidance on common clinical questions related to the provision of lipid emulsions as part of parenteral nutrition (PN). METHODS: The summit was designed to allow interactive discussion and consensus development. The resulting consensus statements represent the collective opinion of the members of the expert panel, which was informed and supported by scientific evidence and clinical experience. RESULTS: The current article summarizes the key discussion topics from the summit and provides a set of consensus statements designed to complement existing evidence-based guidelines. Lipid emulsions are a major component of PN, serving as a condensed source of energy and essential fatty acids. In addition, lipids modulate a variety of biologic functions, including inflammatory and immune responses, coagulation, and cell signaling. A growing body of evidence suggests that lipid emulsions containing ω-3 fatty acids from fish oil confer important clinical benefits via suppression of inflammatory mediators and activation of pathways involved in the resolution of inflammation. CONCLUSIONS: This article provides a set of expert consensus statements to complement formal PN guideline recommendations.
BACKGROUND: The 2018 Lipids in Parenteral Nutrition summit involved a panel of experts in clinical nutrition, lipid metabolism, and pharmacology, to assess the current state of knowledge and develop expert consensus statements regarding the use of intravenous lipid emulsions in various patient populations and clinical settings. The main purpose of the consensus statements is to assist healthcare professionals by providing practical guidance on common clinical questions related to the provision of lipid emulsions as part of parenteral nutrition (PN). METHODS: The summit was designed to allow interactive discussion and consensus development. The resulting consensus statements represent the collective opinion of the members of the expert panel, which was informed and supported by scientific evidence and clinical experience. RESULTS: The current article summarizes the key discussion topics from the summit and provides a set of consensus statements designed to complement existing evidence-based guidelines. Lipid emulsions are a major component of PN, serving as a condensed source of energy and essential fatty acids. In addition, lipids modulate a variety of biologic functions, including inflammatory and immune responses, coagulation, and cell signaling. A growing body of evidence suggests that lipid emulsions containing ω-3 fatty acids from fish oil confer important clinical benefits via suppression of inflammatory mediators and activation of pathways involved in the resolution of inflammation. CONCLUSIONS: This article provides a set of expert consensus statements to complement formal PN guideline recommendations.
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