Literature DB >> 32049045

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.

Sharanya Sivanand1, Matthew G Vander Heiden2.   

Abstract

Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  branched-chain amino acids; cancer metabolism; epigenetics; metabolism

Mesh：

Substances：

Year:  2020        PMID： 32049045      PMCID： PMC7082774          DOI： 10.1016/j.ccell.2019.12.011

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  94 in total

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Review 8.  The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

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Journal:  Nat Med       Date:  2014-09-28       Impact factor: 53.440
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  70 in total

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Review 4.  Signal pathways of melanoma and targeted therapy.

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5.  Integrated omics analysis: the relationship between significantly increased Klebsiella post-hepatectomy and decreased hub-metabolite 3-methyl-2-oxobutanoic acid is associated with induced liver failure.

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6.  Combined screening analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma.

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Review 10.  Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation.

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