Literature DB >> 3204382

The biosynthetic origins of rebeccamycin.

C J Pearce1, T W Doyle, S Forenza, K S Lam, D R Schroeder.   

Abstract

Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the alpha-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.

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Year:  1988        PMID: 3204382     DOI: 10.1021/np50059a020

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  9 in total

1.  Identification of indolepyruvic acid as an intermediate of rebeccamycin biosynthesis.

Authors:  K S Lam; S Forenza; T W Doyle; C J Pearce
Journal:  J Ind Microbiol       Date:  1990-12

2.  Crystallography gets the jump on the enzymologists.

Authors:  David P Ballou
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-26       Impact factor: 11.205

3.  Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.

Authors:  Khaled A Shaaban; Sherif I Elshahawi; Xiachang Wang; Jamie Horn; Madan K Kharel; Markos Leggas; Jon S Thorson
Journal:  J Nat Prod       Date:  2015-06-19       Impact factor: 4.050

4.  Combinatorial biosynthesis of antitumor indolocarbazole compounds.

Authors:  César Sánchez; Lili Zhu; Alfredo F Braña; Aaroa P Salas; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-29       Impact factor: 11.205

5.  Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.

Authors:  Tomoyasu Nishizawa; Courtney C Aldrich; David H Sherman
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

Review 6.  Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives.

Authors:  César Sánchez; Carmen Méndez; José A Salas
Journal:  J Ind Microbiol Biotechnol       Date:  2006-02-21       Impact factor: 3.346

7.  A phase II study of rebeccamycin analog NSC 655649 in patients with metastatic colorectal cancer.

Authors:  Sanjay Goel; Scott Wadler; Anthony Hoffman; Fabio Volterra; Cheryl Baker; Elliot Nazario; Percy Ivy; Alyson Silverman; Sridhar Mani
Journal:  Invest New Drugs       Date:  2003-02       Impact factor: 3.850

Review 8.  The chemistry of isoindole natural products.

Authors:  Klaus Speck; Thomas Magauer
Journal:  Beilstein J Org Chem       Date:  2013-10-10       Impact factor: 2.883

9.  A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite.

Authors:  Fleurdeliz Maglangit; Qing Fang; Kwaku Kyeremeh; Jeremy M Sternberg; Rainer Ebel; Hai Deng
Journal:  Molecules       Date:  2020-01-08       Impact factor: 4.411

  9 in total

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