Literature DB >> 3204376

Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3.

K Sakai1, T Ichikawa, K Yamada, M Yamashita, M Tanimoto, A Hikita, Y Ijuin, K Kondo.   

Abstract

A novel 15-methoxyansamitocin P-3 [2], in company with three known maytansinoids 1, 3, and 4, was isolated for the first time from two Japanese mosses, Isothecium subdiversiforme and Thamnobryum sandei. All are potent cytotoxic compounds.

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Year:  1988        PMID： 3204376     DOI： 10.1021/np50059a005

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Selective isolation and ansamycin-targeted screenings of commensal actinomycetes from the "maytansinoids-producing" arboreal Trewia nudiflora.

Authors:  Na Zhu; Peiji Zhao; Yuemao Shen
Journal:  Curr Microbiol       Date:  2008-10-25       Impact factor: 2.188

2.  Metabolite profiling of the moss Physcomitrella patens reveals evolutionary conservation of osmoprotective substances.

Authors:  Anika Erxleben; Arthur Gessler; Marco Vervliet-Scheebaum; Ralf Reski
Journal:  Plant Cell Rep       Date:  2011-10-29       Impact factor: 4.570

3.  Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes.

Authors:  K Suwanborirux; C J Chang; R W Spjut; J M Cassady
Journal:  Experientia       Date:  1990-01-15

4.  The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.

Authors:  Tin-Wein Yu; Linquan Bai; Dorothee Clade; Dietmar Hoffmann; Sabine Toelzer; Khue Q Trinh; Jun Xu; Steven J Moss; Eckhard Leistner; Heinz G Floss
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205
  4 in total

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