Literature DB >> 32036560

FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8+ T Cells During Ischemic Stroke.

Lizhen Fan1,2, Cun-Jin Zhang1,2, Liwen Zhu1,2, Jian Chen1,2, Zhi Zhang1,2, Pinyi Liu1,2, Xiang Cao1,2, Hailan Meng1,2, Yun Xu3,4,5,6.   

Abstract

CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL specific on CD8+ T cells protected against brain damage and neuron loss. Proteomic analysis identified that PDPK1 functioned downstream of FasL signaling and inhibition of PDPK1 effectively reduced cytotoxicity of CD8+ T cells and improved ischemic neurological deficits. Taken together, these results highlight an intrinsic FasL-PDPK1 pathway regulating the cytotoxicity of CD8+ T cells in ischemic stroke.

Entities:  

Keywords:  CD8+ T cells; FasL; PDPK1; cytotoxicity; neurons; stroke

Mesh：

Substances：

Year:  2020        PMID： 32036560     DOI： 10.1007/s12975-019-00749-0

Source DB:  PubMed          Journal:  Transl Stroke Res        ISSN： 1868-4483            Impact factor:   6.829


  44 in total

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