Theresa Steeb1, Kinan M Hayani2, Paul Förster3, Raffael Liegl3, Frédéric Toussaint1, Max Schlaak2, Carola Berking1, Markus V Heppt4. 1. Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany. 2. Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilians-University, Frauenlobstr. 9-11, 80337, Munich, Germany. 3. Department of Ophthalmology, University Hospital, Ludwig-Maximilians-University, Mathildenstr. 8, 80336, Munich, Germany. 4. Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany. markus.heppt@uk-erlangen.de.
Abstract
PURPOSE: Clinical practice guidelines provide recommendations for the management of diseases. In orphan conditions such as uveal melanoma (UM), guideline developers are challenged to provide practical and useful guidance even in the absence of high-quality evidence. Here, we assessed the methodological quality and identified deficiencies of international guidelines on UM as a base for future guideline development. METHODS: A systematic search was carried out in guideline databases, Medline and Embase until 27th May 2019 for guidelines on UM published between 2004 and 2019. Five independent reviewers assessed the methodological quality of the identified guidelines using the instruments "Appraisal of Guidelines for Research and Evaluation II" (AGREE II) and AGREE-REX (Recommendation EXcellence). Descriptive analysis was performed and subgroup differences were explored with the Kruskal-Wallis (H) test. The relationship between the individual domains and items of the instruments were examined using Spearman's correlation. RESULTS: Five guidelines published from 2014 to 2018 by consortia of the United States of America, Canada and the United Kingdom (UK) were included. The highest scores were obtained by the UK guideline fulfilling 48-86% of criteria in AGREE II and 30-60% for AGREE-REX. All guidelines showed deficiencies in the domains "editorial independence", "applicability", and "recommendation". Subgroup differences were identified only for the domain "editorial independence". CONCLUSION: The UK guideline achieved the highest scores with both instruments and may serve as a basis for future guideline development in UM. The domains "editorial independence", "recommendation", and "applicability" were identified as methodological weaknesses and require particular attention and improvement in future guidelines.
PURPOSE: Clinical practice guidelines provide recommendations for the management of diseases. In orphan conditions such as uveal melanoma (UM), guideline developers are challenged to provide practical and useful guidance even in the absence of high-quality evidence. Here, we assessed the methodological quality and identified deficiencies of international guidelines on UM as a base for future guideline development. METHODS: A systematic search was carried out in guideline databases, Medline and Embase until 27th May 2019 for guidelines on UM published between 2004 and 2019. Five independent reviewers assessed the methodological quality of the identified guidelines using the instruments "Appraisal of Guidelines for Research and Evaluation II" (AGREE II) and AGREE-REX (Recommendation EXcellence). Descriptive analysis was performed and subgroup differences were explored with the Kruskal-Wallis (H) test. The relationship between the individual domains and items of the instruments were examined using Spearman's correlation. RESULTS: Five guidelines published from 2014 to 2018 by consortia of the United States of America, Canada and the United Kingdom (UK) were included. The highest scores were obtained by the UK guideline fulfilling 48-86% of criteria in AGREE II and 30-60% for AGREE-REX. All guidelines showed deficiencies in the domains "editorial independence", "applicability", and "recommendation". Subgroup differences were identified only for the domain "editorial independence". CONCLUSION: The UK guideline achieved the highest scores with both instruments and may serve as a basis for future guideline development in UM. The domains "editorial independence", "recommendation", and "applicability" were identified as methodological weaknesses and require particular attention and improvement in future guidelines.
Authors: Cornelia L A Dewald; Mia-Maria Warnke; Roland Brüning; Martin A Schneider; Peter Wohlmuth; Jan B Hinrichs; Anna Saborowski; Arndt Vogel; Frank K Wacker Journal: Cancers (Basel) Date: 2021-12-27 Impact factor: 6.639
Authors: Anja Wessely; Theresa Steeb; Franz Heppt; Annkathrin Hornung; Matthias D Kaufmann; Elias A T Koch; Frédéric Toussaint; Michael Erdmann; Carola Berking; Markus V Heppt Journal: Curr Oncol Date: 2021-02-19 Impact factor: 3.677
Authors: Theresa Steeb; Anja Wessely; Max Schlaak; Markus V Heppt; Mareike Alter; Christiane Bayerl; Armin Bender; Guido Bruning; Evelyn Dabrowski; Dirk Debus; Nina Devereux; Edgar Dippel; Konstantin Drexler; Pia Dücker; Reinhard Dummer; Steffen Emmert; Peter Elsner; Alexander Enk; Christoffer Gebhardt; Anja Gesierich; Matthias Goebeler; Sergij Goerdt; Steven Goetze; Ralf Gutzmer; Sebastian Haferkamp; Gesina Hansel; Jessica C Hassel; Lucie Heinzerling; Katharina C Kähler; Kjell M Kaume; Wolfgang Krapf; Nicole Kreuzberg; Percy Lehmann; Elisabeth Livingstone; Harald Löffler; Carmen Loquai; Cornelia Mauch; Johanna Mangana; Friedegund Meier; Markus Meissner; Rose K C Moritz; Lara Valeska Maul; Verena Müller; Peter Mohr; Alexander Navarini; Ahn Van Nguyen; Christiane Pfeiffer; Claudia Pföhler; Christian Posch; Erika Richtig; Rainer Rompel; Michael M Sachse; Stefanie Sauder; Dirk Schadendorf; Kerstin Schatton; Hans-Joachim Schulze; Erwin Schultz; Bastian Schilling; Matthias Schmuth; Jan C Simon; Markus Streit; Patrick Terheyden; Alexander Thiem; Thomas Tüting; Julia Welzel; Gerhard Weyandt; Ulrich Wesselmann; Uwe Wollina; Mirjana Ziemer; Lisa Zimmer; Markus Zutt; Carola Berking Journal: J Cancer Res Clin Oncol Date: 2020-11-21 Impact factor: 4.553