Theresa Steeb1,2, Anja Wessely1,2, Max Schlaak3, Markus V Heppt1,2, Mareike Alter4, Christiane Bayerl5, Armin Bender6, Guido Bruning7, Evelyn Dabrowski8, Dirk Debus9, Nina Devereux7, Edgar Dippel8, Konstantin Drexler10, Pia Dücker11, Reinhard Dummer12, Steffen Emmert13, Peter Elsner14, Alexander Enk15, Christoffer Gebhardt16, Anja Gesierich17, Matthias Goebeler17, Sergij Goerdt18, Steven Goetze14, Ralf Gutzmer19, Sebastian Haferkamp10, Gesina Hansel20, Jessica C Hassel15, Lucie Heinzerling1,2,21, Katharina C Kähler22, Kjell M Kaume23, Wolfgang Krapf24, Nicole Kreuzberg25, Percy Lehmann26, Elisabeth Livingstone27, Harald Löffler24, Carmen Loquai28, Cornelia Mauch25, Johanna Mangana12, Friedegund Meier29, Markus Meissner30, Rose K C Moritz31, Lara Valeska Maul32, Verena Müller18, Peter Mohr33, Alexander Navarini32, Ahn Van Nguyen34, Christiane Pfeiffer35,36, Claudia Pföhler37, Christian Posch38, Erika Richtig39, Rainer Rompel40, Michael M Sachse41, Stefanie Sauder40, Dirk Schadendorf27, Kerstin Schatton42, Hans-Joachim Schulze43, Erwin Schultz9, Bastian Schilling17, Matthias Schmuth34, Jan C Simon44, Markus Streit45, Patrick Terheyden46, Alexander Thiem13, Thomas Tüting4, Julia Welzel35, Gerhard Weyandt47, Ulrich Wesselmann26, Uwe Wollina20, Mirjana Ziemer44, Lisa Zimmer27, Markus Zutt23, Carola Berking1,2. 1. Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany. 2. Comprehensive Cancer Center Erlangen, European Metropolitan Region of Nuremberg, Erlangen, Germany. 3. Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilians-University (LMU), Frauenlobstr. 9-11, 80337, Munich, Germany. Max.Schlaak@med.uni-muenchen.de. 4. Department of Dermatology, University Medical Center, Magdeburg, Germany. 5. Department of Dermatology and Allergology, Skin Cancer Center Wiesbaden, Helios Dr. Horst Schmidt Clinics, Wiesbaden, Germany. 6. Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany. 7. Center for Venous and Dermatosurgery, Tabea Krankenhaus Hamburg, Hamburg, Germany. 8. Department of Dermatology, Ludwigshafen Medical Center, Ludwigshafen, Germany. 9. Department of Dermatology, Paracelsus Medical University Nuremberg, City Hospital of Nuremberg, Nuremberg, Germany. 10. Department of Dermatology, University Hospital Regensburg, Regensburg, Germany. 11. Department of Dermatology, Hospital of Dortmund, Dortmund, Germany. 12. Department of Dermatology, University Hospital Zurich, University Zurich, Zürich, Switzerland. 13. Department of Dermatology and Venereology, University Medical Center, Rostock, Germany. 14. Department of Dermatology, University Hospital, Jena, Germany. 15. Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany. 16. Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 17. Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany. 18. Department of Dermatology, Venerology and Allergology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany. 19. Department of Dermatology and Allergy, Hannover Medical School, Skin Cancer Center Hannover, Hannover, Germany. 20. Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany. 21. Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilians-University (LMU), Frauenlobstr. 9-11, 80337, Munich, Germany. 22. Department of Dermatology, Venereology and Allergology, University Medical Center of Schleswig-Holstein, Campus Kiel, Kiel, Germany. 23. Department of Dermatology and Allergology, Klinikum Bremen-Mitte, Bremen, Germany. 24. Department of Dermatology, SLK Hospital Heilbronn, Heilbronn, Germany. 25. Department of Dermatology and Venerology, University of Cologne, Cologne, Germany. 26. Department of Dermatology, Helios University Hospital Wuppertal, Wuppertal, Germany. 27. Department of Dermatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. 28. Department of Dermatology, University Medical Center Mainz, Mainz, Germany. 29. Department of Dermatology, University Hospital Dresden, Dresden, Germany. 30. Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany. 31. Department of Dermatology and Venereology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. 32. Department of Dermatology, University Hospital Basel, Basel, Switzerland. 33. Department of Dermatology, Elbe-Kliniken, Buxtehude, Germany. 34. Department of Dermatology, Venerology and Allergology, Medical University of Innsbruck, Innsbruck, Austria. 35. Department of Dermatology and Allergology, University Hospital Augsburg, Augsburg, Germany. 36. Department of Dermatology and Allergology, University Hospital Ulm, Ulm, Germany. 37. Department of Dermatology, Saarland University Medical Center, Homburg/Saar, Germany. 38. Department of Dermatology and Allergy, School of Medicine, German Cancer Consortium (DKTK), Technical University of Munich, Munich, Germany. 39. Department of Dermatology, Medical University of Graz, Graz, Austria. 40. Department of Dermatology, Klinikum Kassel, Kassel, Germany. 41. Skin Cancer Center, Department of Dermatology, Allergology and Phlebology, Bremerhaven Reinkenheide, Bremerhaven, Germany. 42. Medical Faculty, Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany. 43. Department of Dermatology and Dermato-Histo-Pathology, Fachklinik Hornheide, Skin Cancer Centre, Münster, Germany. 44. Department of Dermatology, Venereology and Allergology, University Medical Center Leipzig, Leipzig, Germany. 45. Department of Dermatology, Hospital Aarau, Aarau, Switzerland. 46. Department of Dermatology, University of Lübeck, Lübeck, Germany. 47. Department of Dermatology and Allergology, Hospital Bayreuth, Bayreuth, Germany.
Abstract
PURPOSE: Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting. METHODS: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Frequency distributions of responses for each item of the questionnaire were calculated. RESULTS: 44 of 70 (62.9%) skin cancer centers completed the questionnaire. Thirty-nine hospitals were located in Germany (88.6%), three in Switzerland (6.8%) and two in Austria (4.5%). The majority (68.2%) represented university hospitals. Most patients with metastatic disease were treated in certified skin cancer centers (70.7%, 29/41). Besides, the majority of patients with UM were referred to the respective skin cancer center by ophthalmologists (87.2%, 34/39). Treatment and organization of follow-up of patients varied across the different centers. 35.1% (14/37) of the centers stated to not perform any screening measures. CONCLUSION: Treatment patterns of patients with uveal melanoma in Germany, Austria and Switzerland remain extremely heterogeneous. A guideline for the treatment and surveillance is urgently needed.
PURPOSE:Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting. METHODS: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Frequency distributions of responses for each item of the questionnaire were calculated. RESULTS: 44 of 70 (62.9%) skin cancer centers completed the questionnaire. Thirty-nine hospitals were located in Germany (88.6%), three in Switzerland (6.8%) and two in Austria (4.5%). The majority (68.2%) represented university hospitals. Most patients with metastatic disease were treated in certified skin cancer centers (70.7%, 29/41). Besides, the majority of patients with UM were referred to the respective skin cancer center by ophthalmologists (87.2%, 34/39). Treatment and organization of follow-up of patients varied across the different centers. 35.1% (14/37) of the centers stated to not perform any screening measures. CONCLUSION: Treatment patterns of patients with uveal melanoma in Germany, Austria and Switzerland remain extremely heterogeneous. A guideline for the treatment and surveillance is urgently needed.
Authors: S Mallone; E De Vries; M Guzzo; E Midena; J Verne; J W Coebergh; R Marcos-Gragera; E Ardanaz; R Martinez; M D Chirlaque; C Navarro; G Virgili Journal: Eur J Cancer Date: 2011-11-25 Impact factor: 9.162
Authors: Markus V Heppt; Lucie Heinzerling; Katharina C Kähler; Andrea Forschner; Michael C Kirchberger; Carmen Loquai; Markus Meissner; Friedegund Meier; Patrick Terheyden; Beatrice Schell; Rudolf Herbst; Daniela Göppner; Felix Kiecker; David Rafei-Shamsabadi; Sebastian Haferkamp; Margit A Huber; Jochen Utikal; Mirjana Ziemer; Irmgard Bumeder; Christiane Pfeiffer; Susanne G Schäd; Christoph Schmid-Tannwald; Julia K Tietze; Thomas K Eigentler; Carola Berking Journal: Eur J Cancer Date: 2017-06-22 Impact factor: 9.162
Authors: Chandrani Chattopadhyay; Dae Won Kim; Dan S Gombos; Junna Oba; Yong Qin; Michelle D Williams; Bita Esmaeli; Elizabeth A Grimm; Jennifer A Wargo; Scott E Woodman; Sapna P Patel Journal: Cancer Date: 2016-03-15 Impact factor: 6.860
Authors: Markus V Heppt; Theresa Steeb; Justin Gabriel Schlager; Stefanie Rosumeck; Corinna Dressler; Thomas Ruzicka; Alexander Nast; Carola Berking Journal: Cancer Treat Rev Date: 2017-08-24 Impact factor: 12.111
Authors: Nathaniel Liddy; Giovanna Bossi; Katherine J Adams; Anna Lissina; Tara M Mahon; Namir J Hassan; Jessie Gavarret; Frayne C Bianchi; Nicholas J Pumphrey; Kristin Ladell; Emma Gostick; Andrew K Sewell; Nikolai M Lissin; Naomi E Harwood; Peter E Molloy; Yi Li; Brian J Cameron; Malkit Sami; Emma E Baston; Penio T Todorov; Samantha J Paston; Rebecca E Dennis; Jane V Harper; Steve M Dunn; Rebecca Ashfield; Andy Johnson; Yvonne McGrath; Gabriela Plesa; Carl H June; Michael Kalos; David A Price; Annelise Vuidepot; Daniel D Williams; Deborah H Sutton; Bent K Jakobsen Journal: Nat Med Date: 2012-06 Impact factor: 53.440
Authors: Markus V Heppt; Teresa Amaral; Katharina C Kähler; Lucie Heinzerling; Jessica C Hassel; Markus Meissner; Nicole Kreuzberg; Carmen Loquai; Lydia Reinhardt; Jochen Utikal; Evelyn Dabrowski; Anja Gesierich; Claudia Pföhler; Patrick Terheyden; Kai-Martin Thoms; Lisa Zimmer; Thomas K Eigentler; Michael C Kirchberger; Henner M Stege; Friedegund Meier; Max Schlaak; Carola Berking Journal: J Immunother Cancer Date: 2019-11-13 Impact factor: 13.751
Authors: Richard D Carvajal; Gary K Schwartz; Tongalp Tezel; Brian Marr; Jasmine H Francis; Paul D Nathan Journal: Br J Ophthalmol Date: 2016-08-29 Impact factor: 4.638