Noora Houttu1, Marko Kalliomäki2, Minna-Maija Grönlund3, Harri Niinikoski4, Merja Nermes5, Kirsi Laitinen6. 1. Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address: nhmhou@utu.fi. 2. Department of Pediatrics, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: markal@utu.fi. 3. Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: minna-maija.gronlund@tyks.fi. 4. Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland; Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: hjniin@utu.fi. 5. Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: merja.nermes@tyks.fi. 6. Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. Electronic address: kirsi.laitinen@utu.fi.
Abstract
BACKGROUND & AIMS: Aberrations in body composition are expected in children suffering from chronic inflammatory conditions. The objective is to examine whether children with inflammatory bowel disease (IBD: Crohn's disease and ulcerative colitis), coeliac disease, asthma and juvenile idiopathic arthritis (JIA) have an altered body composition as compared to healthy children. METHODS: A systematic review, registered in Prospero (registration number: CRD42018107645), was conducted according to PRISMA guidelines. We conducted a search of three databases, Pubmed, Cochrane and Scopus. An assessment of the quality of the study was performed. RESULTS: Data from 50 studies, 32 with IBD, 8 with coeliac disease, 2 with asthma and 8 with JIA, involving 2399 children were selected for review after applying the eligibility criteria. In all but 4 studies, children with Crohn's disease exhibited decreased amounts of fat mass and fat free mass. Reductions in fat mass were also evident in studies in children with coeliac disease. It is uncertain whether body composition is altered in children with asthma or JIA. CONCLUSIONS: Children with Crohn's disease manifest with lowered adiposity and lean mass and therefore are likely to be at risk for suffering malnutrition-related clinical complications. Apart from Crohn's disease, data examining body composition in children with chronic inflammatory conditions are scarce and there is a paucity of reports examining the relationship between inflammation and body composition. Interpretation of the current study results is hampered by the low quality of the studies and due to the fact that the analyses have been habitually secondary outcomes.
BACKGROUND & AIMS: Aberrations in body composition are expected in children suffering from chronic inflammatory conditions. The objective is to examine whether children with inflammatory bowel disease (IBD: Crohn's disease and ulcerative colitis), coeliac disease, asthma and juvenile idiopathic arthritis (JIA) have an altered body composition as compared to healthy children. METHODS: A systematic review, registered in Prospero (registration number: CRD42018107645), was conducted according to PRISMA guidelines. We conducted a search of three databases, Pubmed, Cochrane and Scopus. An assessment of the quality of the study was performed. RESULTS: Data from 50 studies, 32 with IBD, 8 with coeliac disease, 2 with asthma and 8 with JIA, involving 2399 children were selected for review after applying the eligibility criteria. In all but 4 studies, children with Crohn's disease exhibited decreased amounts of fat mass and fat free mass. Reductions in fat mass were also evident in studies in children with coeliac disease. It is uncertain whether body composition is altered in children with asthma or JIA. CONCLUSIONS:Children with Crohn's disease manifest with lowered adiposity and lean mass and therefore are likely to be at risk for suffering malnutrition-related clinical complications. Apart from Crohn's disease, data examining body composition in children with chronic inflammatory conditions are scarce and there is a paucity of reports examining the relationship between inflammation and body composition. Interpretation of the current study results is hampered by the low quality of the studies and due to the fact that the analyses have been habitually secondary outcomes.
Authors: Antoinette A Amevor; Toshifumi Yodoshi; Andrew T Trout; Jonathan R Dillman; Ruchi Singh; Ryan Jarvis; Lin Fei; Chunyan Liu; Amy Taylor; Alexander Miethke; Marialena Mouzaki Journal: Liver Int Date: 2021-11-29 Impact factor: 8.754