| Literature DB >> 32030522 |
Alejandra González-Duarte1, John L Berk2, Dianna Quan3, Michelle L Mauermann4, Hartmut H Schmidt5, Michael Polydefkis6, Márcia Waddington-Cruz7, Mitsuharu Ueda8, Isabel M Conceição9, Arnt V Kristen10, Teresa Coelho11, Cécile A Cauquil12, Céline Tard13, Madeline Merkel14, Emre Aldinc14, Jihong Chen14, Marianne T Sweetser14, Jing Jing Wang14, David Adams15.
Abstract
The original version of this article unfortunately contained a mistake.Entities:
Year: 2020 PMID: 32030522 PMCID: PMC7035215 DOI: 10.1007/s00415-020-09715-5
Source DB: PubMed Journal: J Neurol ISSN: 0340-5354 Impact factor: 4.849
Disease characteristics of autonomic endpoints at baseline
| Characteristic | Placebo ( | Patisiran ( | Total ( |
|---|---|---|---|
| COMPASS-31 total score (range 0–100), mean (± SD) | 30.3 (16.4) | 30.6 (17.6) | 30.5 (17.1) |
| Orthostatic intolerance (range: 0–40), mean (± SD) | 13.2 (11.2) | 14.2 (10.8) | 13.8 (10.9) |
| Vasomotor (range 0–5), mean (± SD) | 1.0 (1.4) | 0.9 (1.44) | 1.0 (1.4) |
| Secretomotor (range 0–15), mean (± SD) | 4.9 (3.7) | 4.2 (3.7) | 4.4 (3.7) |
| Gastrointestinal (range 0–25), mean (± SD) | 8.1 (3.5) | 8.2 (4.3) | 8.1 (4.1) |
| Bladder (range 0–10), mean (± SD) | 1.9 (2.7) | 2.0 (2.5) | 2.0 (2.5) |
| Pupillomotor (range 0–5), mean (± SD) | 1.1 (1.1) | 1.2 (1.2) | 1.2 (1.2) |
| mBMI (kg/m2 × g/L), mean (± SD) | 989.9 (214.2) | 969.7 (210.5) | 976.6 (211.5) |
| BMI (kg/m2), mean (± SD) | 23.6 (4.3) | 23.0 (4.4) | 23.2 (4.4) |
| Albumin (g/L), mean (± SD) | 41.8 (3.4) | 42.1 (3.5) | 42.0 (3.5) |
| Weight (kg), mean (± SD) | 67.5 (15.7) | 67.3 (16.6) | 67.4 (16.3) |
| mNIS + 7 total score (range 0–304), mean (± SD) | 74.6 (37.0) | 80.9 (41.5) | 78.8 (40.1) |
| Postural blood pressure (range 0–2), mean (± SD) | 0.6 (0.7) | 0.7 (0.8) | 0.6 (0.8) |
| Norfolk QOL-DN total score (range − 4 to 136), mean (± SD) | 55.5 (24.3) | 59.6 (28.2) | 58.3 (27.0) |
| Autonomic neuropathy domain (range 0–12), mean (± SD) | 2.9 (2.9) | 3.0 (2.8) | 3.0 (2.8) |
BMI body mass index, COMPASS-31 Composite Autonomic Symptom Score-31, mBMI modified body mass index, mNIS + 7 modified Neuropathy Impairment Score + 7, Norfolk QOL-DN Norfolk Quality of Life-Diabetic Neuropathy