Paola Magioncalda1, Matteo Martino2, Benedetta Conio3, Hsin-Chien Lee4, Hsiao-Lun Ku5, Chi-Jen Chen6, Matilde Inglese7, Mario Amore8, Timothy J Lane9, Georg Northoff10. 1. Brain and Consciousness Research Center, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan; Graduate Institute of Mind Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. Electronic address: paola.magioncalda@gmail.com. 2. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: matteomartino9@gmail.com. 3. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy. Electronic address: benedetta.conio@hotmail.it. 4. Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address: ellalee@tmu.edu.tw. 5. Department of Psychiatry, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan. Electronic address: doctorku0610@gmail.com. 6. Department of Radiology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan. Electronic address: 08889@s.tmu.edu.tw. 7. Ospedale Policlinico San Martino IRCCS, Genoa, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Neurology, University of Genoa, Genoa, Italy. Electronic address: m.inglese@unige.it. 8. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy. Electronic address: mario.amore@unige.it. 9. Brain and Consciousness Research Center, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan; Graduate Institute of Mind Brain and Consciousness, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: timlane@tmu.edu.tw. 10. Mind Brain Imaging and Neuroethics Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, Canada; Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China; Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. Electronic address: georg.northoff@theroyal.ca.
Abstract
OBJECTIVE: Alterations in psychomotor dimension cut across different psychiatric disorders, such as schizophrenia (SCZ) and bipolar disorder (BD). This preliminary study aimed to investigate the organization of intrinsic brain activity in the subcortical-cortical sensorimotor system in SCZ (and BD) as characterized according to psychomotor dimension. METHOD: In this resting-state functional magnetic resonance imaging (fMRI) study, functional connectivity (FC) between thalamus and sensorimotor network (SMN), along with FC from substantia nigra (SN) and raphe nuclei (RN) to basal ganglia (BG) and thalamic regions, were investigated by using an a-priori-driven and dimensional approach. This was done in two datasets: SCZ patients showing inhibited psychomotricity (n = 18) vs. controls (n = 19); SCZ patients showing excited psychomotricity (n = 20) vs. controls (n = 108). Data from a third dataset of BD in inhibited depressive or manic phases (reflecting inhibited or excited psychomotricity) were used as control. RESULTS: SCZ patients suffering from psychomotor inhibition showed decreased thalamus-SMN FC toward around-zero values paralleled by a concomitant reduction of SN-BG/thalamus FC and RN-BG/thalamus FC (as BD patients in inhibited depression). By contrast, SCZ patients suffering from psychomotor excitation exhibited increased thalamus-SMN FC toward positive values paralleled by a concomitant reduction of RN-BG/thalamus FC (as BD patients in mania). CONCLUSIONS: These findings suggest that patients exhibiting low or high levels of psychomotor activity show distinct patterns of thalamus-SMN coupling, which could be traced to specific deficit in SN- or RN-related connectivity. Notably, this was independent from the diagnosis of SCZ or BD, supporting an RDoC-like dimensional approach to psychomotricity.
OBJECTIVE: Alterations in psychomotor dimension cut across different psychiatric disorders, such as schizophrenia (SCZ) and bipolar disorder (BD). This preliminary study aimed to investigate the organization of intrinsic brain activity in the subcortical-cortical sensorimotor system in SCZ (and BD) as characterized according to psychomotor dimension. METHOD: In this resting-state functional magnetic resonance imaging (fMRI) study, functional connectivity (FC) between thalamus and sensorimotor network (SMN), along with FC from substantia nigra (SN) and raphe nuclei (RN) to basal ganglia (BG) and thalamic regions, were investigated by using an a-priori-driven and dimensional approach. This was done in two datasets: SCZpatients showing inhibited psychomotricity (n = 18) vs. controls (n = 19); SCZpatients showing excited psychomotricity (n = 20) vs. controls (n = 108). Data from a third dataset of BD in inhibited depressive or manic phases (reflecting inhibited or excited psychomotricity) were used as control. RESULTS:SCZpatients suffering from psychomotor inhibition showed decreased thalamus-SMN FC toward around-zero values paralleled by a concomitant reduction of SN-BG/thalamus FC and RN-BG/thalamus FC (as BDpatients in inhibited depression). By contrast, SCZpatients suffering from psychomotor excitation exhibited increased thalamus-SMN FC toward positive values paralleled by a concomitant reduction of RN-BG/thalamus FC (as BDpatients in mania). CONCLUSIONS: These findings suggest that patients exhibiting low or high levels of psychomotor activity show distinct patterns of thalamus-SMN coupling, which could be traced to specific deficit in SN- or RN-related connectivity. Notably, this was independent from the diagnosis of SCZ or BD, supporting an RDoC-like dimensional approach to psychomotricity.
Authors: Katherine S F Damme; Jadyn S Park; Sebastian Walther; Teresa Vargas; Stewart A Shankman; Vijay A Mittal Journal: Schizophr Bull Date: 2022-06-21 Impact factor: 7.348
Authors: Dusan Hirjak; Stefan Fritze; Georg Northoff; Katharina M Kubera; Robert Christian Wolf Journal: Nervenarzt Date: 2021-06-11 Impact factor: 1.214
Authors: Dimitri Van De Ville; Patrik Vuilleumier; Gwladys Rey; Thomas A W Bolton; Julian Gaviria; Camille Piguet; Maria Giulia Preti; Sophie Favre; Jean-Michel Aubry Journal: Neuropsychopharmacology Date: 2021-06-07 Impact factor: 7.853