Jiaquan Liang1,2, Wei Huang3, Huagui Guo3, Weibin Wu3, Xiaoling Li3, Caixia Xu3, Guojun Xie3, Wensheng Chen4. 1. Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China. 417891714@qq.com. 2. Center on Translational Neuroscience, Minzu University of China, Beijing, People's Republic of China. 417891714@qq.com. 3. Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China. 4. Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China. cws1128@163.com.
Abstract
BACKGROUND: Bipolar disorder (BD) and schizophrenia (SC) have many similarities in clinical manifestations. The acute phase of BD has psychotic symptoms, while SC also has emotional symptoms during the onset, which suggests that there is some uncertainty in distinguishing BD and SC through clinical symptoms. AIM: To explore the characteristics of brain functional activities and cognitive impairment between BD and SC. METHODS: Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test was performed on patients in drug-naïve BD and SC (50 subjects in each group), and resting-state functional magnetic resonance imaging (rs-fMRI) scanning was performed meanwhile. Rs-fMRI data were routinely preprocessed, and the value of the fractional amplitude of low-frequency fluctuation (fALFF) was calculated. Then each part of the scores of the RBANS and the characteristics of brain function activities were compared between the two groups. Finally used Pearson correlation to analyze the correlation between cognition and brain function. RESULTS: (1) Compared with BD group, all parts of RBANS scores in SC group decreased; (2) The left inferior occipital gyrus (IOG, peak coordinates - 30, -87, -15; t = 4.78, voxel size = 31, Alphasim correction) and the right superior temporal gyrus (STG, peak coordinates 51, -12, 0; t = 5.08, voxel size = 17, AlphaSim correction) were the brain areas with significant difference in fALFF values between BD and SC. Compared with SC group, the fALFF values of the left IOG and the right STG in BD group were increased (p < 0.05); (3) Pearson correlation analysis showed that the visuospatial construction score was positively correlated with the fALFF values of the left IOG and the right STG (rleft IOG = 0.304, p = 0.003; rright STG = 0.340, p = 0.001); The delayed memory (figure recall) score was positively correlated with the fALFF value of the left IOG (rleft IOG = 0.207, p = 0.044). DISCUSSION: The cognitive impairment of SC was more serious than BD. The abnormal activities of the left IOG and the right STG may be the core brain region to distinguish BD and SC, and are closely related to cognitive impairment, which provide neuroimaging basis for clinical differential diagnosis and explore the pathological mechanism of cognitive impairment.
BACKGROUND: Bipolar disorder (BD) and schizophrenia (SC) have many similarities in clinical manifestations. The acute phase of BD has psychotic symptoms, while SC also has emotional symptoms during the onset, which suggests that there is some uncertainty in distinguishing BD and SC through clinical symptoms. AIM: To explore the characteristics of brain functional activities and cognitive impairment between BD and SC. METHODS: Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test was performed on patients in drug-naïve BD and SC (50 subjects in each group), and resting-state functional magnetic resonance imaging (rs-fMRI) scanning was performed meanwhile. Rs-fMRI data were routinely preprocessed, and the value of the fractional amplitude of low-frequency fluctuation (fALFF) was calculated. Then each part of the scores of the RBANS and the characteristics of brain function activities were compared between the two groups. Finally used Pearson correlation to analyze the correlation between cognition and brain function. RESULTS: (1) Compared with BD group, all parts of RBANS scores in SC group decreased; (2) The left inferior occipital gyrus (IOG, peak coordinates - 30, -87, -15; t = 4.78, voxel size = 31, Alphasim correction) and the right superior temporal gyrus (STG, peak coordinates 51, -12, 0; t = 5.08, voxel size = 17, AlphaSim correction) were the brain areas with significant difference in fALFF values between BD and SC. Compared with SC group, the fALFF values of the left IOG and the right STG in BD group were increased (p < 0.05); (3) Pearson correlation analysis showed that the visuospatial construction score was positively correlated with the fALFF values of the left IOG and the right STG (rleft IOG = 0.304, p = 0.003; rright STG = 0.340, p = 0.001); The delayed memory (figure recall) score was positively correlated with the fALFF value of the left IOG (rleft IOG = 0.207, p = 0.044). DISCUSSION: The cognitive impairment of SC was more serious than BD. The abnormal activities of the left IOG and the right STG may be the core brain region to distinguish BD and SC, and are closely related to cognitive impairment, which provide neuroimaging basis for clinical differential diagnosis and explore the pathological mechanism of cognitive impairment.
Authors: Roger S McIntyre; Michael Berk; Elisa Brietzke; Benjamin I Goldstein; Carlos López-Jaramillo; Lars Vedel Kessing; Gin S Malhi; Andrew A Nierenberg; Joshua D Rosenblat; Amna Majeed; Eduard Vieta; Maj Vinberg; Allan H Young; Rodrigo B Mansur Journal: Lancet Date: 2020-12-05 Impact factor: 79.321
Authors: Leila Nabulsi; Genevieve McPhilemy; Liam Kilmartin; Joseph R Whittaker; Fiona M Martyn; Brian Hallahan; Colm McDonald; Kevin Murphy; Dara M Cannon Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2019-11-11
Authors: Genevieve McPhilemy; Leila Nabulsi; Liam Kilmartin; Joseph R Whittaker; Fiona M Martyn; Brian Hallahan; Colm McDonald; Kevin Murphy; Dara M Cannon Journal: Brain Connect Date: 2020-07-21
Authors: Judith Allardyce; Ganna Leonenko; Marian Hamshere; Antonio F Pardiñas; Liz Forty; Sarah Knott; Katherine Gordon-Smith; David J Porteous; Caroline Haywood; Arianna Di Florio; Lisa Jones; Andrew M McIntosh; Michael J Owen; Peter Holmans; James T R Walters; Nicholas Craddock; Ian Jones; Michael C O'Donovan; Valentina Escott-Price Journal: JAMA Psychiatry Date: 2018-01-01 Impact factor: 25.911