Sanne J E Bruijniks1, Lotte H J M Lemmens2, Steven D Hollon3, Frenk P M L Peeters4, Pim Cuijpers5, Arnoud Arntz6, Pieter Dingemanse7, Linda Willems8, Patricia van Oppen9, Jos W R Twisk10, Michael van den Boogaard11, Jan Spijker12, Judith Bosmans13, Marcus J H Huibers14. 1. Postdoctoral Researcher, Department of Clinical Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, The Netherlands; and Department of Clinical Psychology and Psychotherapy, University of Freiburg, Germany. 2. Assistant Professor, Department of Clinical Psychological Science, Maastricht University, The Netherlands. 3. Professor, Department of Psychology, Vanderbilt University, Tennessee, USA. 4. Professor, Department of Clinical Psychological Science, Maastricht University, The Netherlands. 5. Professor, Department of Clinical Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, The Netherlands. 6. Professor, Department of Clinical Psychology, University of Amsterdam, The Netherlands. 7. Clinical Psychologist, Department of Mood Disorders, Altrecht Mental Health Institute, The Netherlands. 8. Health Care Psychologist, Department of Mood Disorders, GGZ Oost Brabant, The Netherlands. 9. Professor, Department of Psychiatry, Amsterdam UMC, Vrije Universiteit/GGZ inGeest and Public Health Research Institute, The Netherlands. 10. Professor, Department of Epidemiology and Biostatistics, VU University Medical Center, The Netherlands. 11. Senior Researcher, Department of Affective Disorders, PsyQ, Parnassia Group, The Netherlands. 12. Professor, Center of Depression Expertise, Pro Persona Mental Health Care; and Behavioural Science Institute, Radboud University Nijmegen, The Netherlands. 13. Associate Professor, Department of Health Sciences, Amsterdam Public Health Research Institute, Faculty of Earth and Life Sciences, Section of Health Economics & Health Technology Assessment, Vrije Universiteit Amsterdam, The Netherlands. 14. Professor, Department of Clinical Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, The Netherlands; and Department of Psychology, University of Pennsylvania, Philadelphia, USA.
Abstract
BACKGROUND: It is unclear what session frequency is most effective in cognitive-behavioural therapy (CBT) and interpersonal psychotherapy (IPT) for depression. AIMS: Compare the effects of once weekly and twice weekly sessions of CBT and IPT for depression. METHOD: We conducted a multicentre randomised trial from November 2014 through December 2017. We recruited 200 adults with depression across nine specialised mental health centres in the Netherlands. This study used a 2 × 2 factorial design, randomising patients to once or twice weekly sessions of CBT or IPT over 16-24 weeks, up to a maximum of 20 sessions. Main outcome measures were depression severity, measured with the Beck Depression Inventory-II at baseline, before session 1, and 2 weeks, 1, 2, 3, 4, 5 and 6 months after start of the intervention. Intention-to-treat analyses were conducted. RESULTS: Compared with patients who received weekly sessions, patients who received twice weekly sessions showed a statistically significant decrease in depressive symptoms (estimated mean difference between weekly and twice weekly sessions at month 6: 3.85 points, difference in effect size d = 0.55), lower attrition rates (n = 16 compared with n = 32) and an increased rate of response (hazard ratio 1.48, 95% CI 1.00-2.18). CONCLUSIONS: In clinical practice settings, delivery of twice weekly sessions of CBT and IPT for depression is a way to improve depression treatment outcomes.
RCT Entities:
BACKGROUND: It is unclear what session frequency is most effective in cognitive-behavioural therapy (CBT) and interpersonal psychotherapy (IPT) for depression. AIMS: Compare the effects of once weekly and twice weekly sessions of CBT and IPT for depression. METHOD: We conducted a multicentre randomised trial from November 2014 through December 2017. We recruited 200 adults with depression across nine specialised mental health centres in the Netherlands. This study used a 2 × 2 factorial design, randomising patients to once or twice weekly sessions of CBT or IPT over 16-24 weeks, up to a maximum of 20 sessions. Main outcome measures were depression severity, measured with the Beck Depression Inventory-II at baseline, before session 1, and 2 weeks, 1, 2, 3, 4, 5 and 6 months after start of the intervention. Intention-to-treat analyses were conducted. RESULTS: Compared with patients who received weekly sessions, patients who received twice weekly sessions showed a statistically significant decrease in depressive symptoms (estimated mean difference between weekly and twice weekly sessions at month 6: 3.85 points, difference in effect size d = 0.55), lower attrition rates (n = 16 compared with n = 32) and an increased rate of response (hazard ratio 1.48, 95% CI 1.00-2.18). CONCLUSIONS: In clinical practice settings, delivery of twice weekly sessions of CBT and IPT for depression is a way to improve depression treatment outcomes.
Authors: Kenneth E Freedland; Judith A Skala; Robert M Carney; Brian C Steinmeyer; Eugene H Rubin; Michael W Rich Journal: Circ Heart Fail Date: 2022-06-21 Impact factor: 10.447
Authors: Philippa Gebhardt; Flora Caldarone; Mechthild Westhoff-Bleck; Karen M Olsson; Marius M Hoeper; Da-Hee Park; Britta Stapel; Michael H Breitner; Oliver Werth; Ivo Heitland; Kai G Kahl Journal: Front Psychiatry Date: 2022-04-04 Impact factor: 5.435