N L Sandi-Monroy1,2, S Musanovic3,4, D Zhu3,4, K Eibner4,5, N Reeka4,5, J Koglin4,5, K Bundschu5,6, F Gagsteiger4,5. 1. IVF Laboratory, Kinderwunsch-MVZ Ulm GmbH, Einsteinstrasse 59, 89077, Ulm, Germany. sandi-monroy@kwz-ulm.de. 2. NextClinics International GmbH, 86482, Aystetten, Germany. sandi-monroy@kwz-ulm.de. 3. IVF Laboratory, Kinderwunsch-MVZ Ulm GmbH, Einsteinstrasse 59, 89077, Ulm, Germany. 4. NextClinics International GmbH, 86482, Aystetten, Germany. 5. Medical Department, Kinderwunsch-MVZ Ulm GmbH, Einsteinstrasse 59, 89077, Ulm, Germany. 6. Frauenheilkunde und Geburtshilfe, Universitätsklinikum Ulm, Prittwitzstrasse 43, 89075, Ulm, Germany.
Abstract
PURPOSE: To describe an interesting not previously described morphokinetic finding. METHODS: Retrospective case report of a couple undergoing controlled ovarian stimulation (COS) followed by in vitro fertilization and blastocyst transfer. RESULTS: We identified a unique finding of blastulation of a fertilized human zygote after conventional in vitro fertilization. The fertilized zygote did not show any clear cytokinesis until approximately 107 h post insemination, when it started dividing into a blastocyst. By 113 h post insemination, inner cell mass and trophectoderm cells could be clearly distinguished and the blastocyst was completely hatched by 136 h post insemination. CONCLUSION: Time-lapse systems offer more detailed observations of embryonic development. Here, we report an atypical development of an embryo that was not described previously. We hope to become an insightful discussion among peers and incentive the publication of such findings in the future.
PURPOSE: To describe an interesting not previously described morphokinetic finding. METHODS: Retrospective case report of a couple undergoing controlled ovarian stimulation (COS) followed by in vitro fertilization and blastocyst transfer. RESULTS: We identified a unique finding of blastulation of a fertilized human zygote after conventional in vitro fertilization. The fertilized zygote did not show any clear cytokinesis until approximately 107 h post insemination, when it started dividing into a blastocyst. By 113 h post insemination, inner cell mass and trophectoderm cells could be clearly distinguished and the blastocyst was completely hatched by 136 h post insemination. CONCLUSION: Time-lapse systems offer more detailed observations of embryonic development. Here, we report an atypical development of an embryo that was not described previously. We hope to become an insightful discussion among peers and incentive the publication of such findings in the future.
Authors: G Coticchio; M Mignini Renzini; P V Novara; M Lain; E De Ponti; D Turchi; R Fadini; M Dal Canto Journal: Hum Reprod Date: 2018-01-01 Impact factor: 6.918