INTRODUCTION: The injuries of achilles tendon which is among the most important tendons in the body include many problems. Limited tendon recovery is provided through the surgical procedures available. Re-rupture occurs during and after recovery and the long time it takes to return to work, impossibility of early movement of the affected ankle and not being able to provide a physiological recovery in tendon constitute a problem. Thus, our objective in this study was to demonstrate the recovery effects of Retendon (mucopolygen complex) on achilles tendon. MATERIAL- METHOD: After taking the consent of the ethics board we applied for animal experiments, the experiment animals in our study were separated into two groups as those which were given Retendo® (Mucopolygen Complex - Mucopolysaccharides, Hydrolyzed Collagen Type I, Vitamin C) and the control group. These two groups were separated into four groups. In a total of eight groups, 40 female Wistar-Albino rats with an average weight of 200-350 gr. were included in the study. RESULTS: The study had biomechanical and histological results. While there was no significant difference in vascularization, inflamation and fibroblastic level among the groups in histological terms, collagen formation was detected to be more regular in the experiment group than the control group. A significant efficiency couldn't be acquired in biomechanical terms. DISCUSSION: Although Retendo® (mucopolygen complex) is commonly used in muscle and tendon diseases, its effect mechanism is not definitely known. But in the light of the findings we acquired in our study, we detected that Retendo® (mucopolygen complex) applied after achilles tendon ruptures positively effected collagen sequencing during recovery in histological terms but didn't have a significant effect on the mean load achilles tendon can tolerate before rupturing.
INTRODUCTION: The injuries of achilles tendon which is among the most important tendons in the body include many problems. Limited tendon recovery is provided through the surgical procedures available. Re-rupture occurs during and after recovery and the long time it takes to return to work, impossibility of early movement of the affected ankle and not being able to provide a physiological recovery in tendon constitute a problem. Thus, our objective in this study was to demonstrate the recovery effects of Retendon (mucopolygen complex) on achilles tendon. MATERIAL- METHOD: After taking the consent of the ethics board we applied for animal experiments, the experiment animals in our study were separated into two groups as those which were given Retendo® (Mucopolygen Complex - Mucopolysaccharides, Hydrolyzed Collagen Type I, Vitamin C) and the control group. These two groups were separated into four groups. In a total of eight groups, 40 female Wistar-Albino rats with an average weight of 200-350 gr. were included in the study. RESULTS: The study had biomechanical and histological results. While there was no significant difference in vascularization, inflamation and fibroblastic level among the groups in histological terms, collagen formation was detected to be more regular in the experiment group than the control group. A significant efficiency couldn't be acquired in biomechanical terms. DISCUSSION: Although Retendo® (mucopolygen complex) is commonly used in muscle and tendon diseases, its effect mechanism is not definitely known. But in the light of the findings we acquired in our study, we detected that Retendo® (mucopolygen complex) applied after achilles tendon ruptures positively effected collagen sequencing during recovery in histological terms but didn't have a significant effect on the mean load achilles tendon can tolerate before rupturing.